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Cell-to-cell interactions in cultures of swine bone marrow cells and CPK-66b cells infected with african swine fever virus

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In the presence of specific antiserum, cultured bone marrow cells from pigs infected with African swine fever virus form cell-to-cell junctions which are morphologically similar to those observed in antibody-dependent cellular cytotoxicity. This type of cytotoxicity does not determine the reaction of delayed hemadsorption, since this reaction is realized in a long-term culture of CPK-66b cells in the absence of the effectors of antibody-dependent cellular cytotoxicity. The sensitivity of delayed hemadsorption depends on the variant of infecting virus. A negative correlation is established between the area of the contact between erythrocytes and cells infected with different variants of the virus, on the one hand, and titers of antibodies in the delayed hemadsorption reaction, on the other.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Institute of Veterinary Virology and Microbiology, Pokrov

    N. G. Shubina, A. A. Kolontsov, M. S. Malakhova & V. V. Makarov

Authors
  1. N. G. Shubina
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  2. A. A. Kolontsov
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  3. M. S. Malakhova
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  4. V. V. Makarov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 418–424, October, 1996

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Shubina, N.G., Kolontsov, A.A., Malakhova, M.S. et al. Cell-to-cell interactions in cultures of swine bone marrow cells and CPK-66b cells infected with african swine fever virus. Bull Exp Biol Med 122, 1014–1020 (1996). https://doi.org/10.1007/BF02447024

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  • DOI: https://doi.org/10.1007/BF02447024

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