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Infection of highly differentiated human and guinea pig astrocytes with herpes simplex and measles viruses

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The morphogenesis of type I herpes simplex virus and measles virus (Edmonston strain) is studied in primary cultures of highly differentiated human and guinea pig astrocytes. It is shown that astrocytes are involved in infection. Under varied conditions of inoculation, herpes simplex virus causes acute infection, while measles virus induces both acute and chronic infection. Chronic infection is associated with impaired assembly of virions, accumulation of thickened ribonucleoproteins (25–37 nm in diameter) in the cytoplasm, and budding of “empty” viral particles into the extracellular space. Persisting measles virus reactivates 78±9.4% of cells, which is accompanied by hypertrophy and hyperproduction of the glial fibrillar acid protein.

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Authors and Affiliations

  1. Byelorussian Institute of Epidemiology and Microbiology, Byelorussian Ministra of Health, Minsk

    N. N. Poleshchuk, Z. B. Kvacheva, Yu. G. Ul'kevich & E. D. Cherstvoi

  2. Minsk State Medical Institute, Minsk, USSR

    N. N. Poleshchuk, Z. B. Kvacheva, Yu. G. Ul'kevich & E. D. Cherstvoi

Authors
  1. N. N. Poleshchuk
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  2. Z. B. Kvacheva
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  3. Yu. G. Ul'kevich
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  4. E. D. Cherstvoi
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 413–417, October, 1996

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Poleshchuk, N.N., Kvacheva, Z.B., Ul'kevich, Y.G. et al. Infection of highly differentiated human and guinea pig astrocytes with herpes simplex and measles viruses. Bull Exp Biol Med 122, 1010–1014 (1996). https://doi.org/10.1007/BF02447023

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  • DOI: https://doi.org/10.1007/BF02447023

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