Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 4, pp 1007–1009 | Cite as

Antiedematous effect of the preparation Polyosm in brain ischemia

  • M. B. Plotnikov
  • V. I. Smol'yakova
  • G. A. Chernysheva
Pharmacology and Toxicology


The effect of the preparation Polyosm (polyethylene oxide 400) on cerebral edema (impedance measurements) and cerebral circulation is studied in brain ischemia caused by ligation of the left common carotid artery and reduction of blood flow through the right common carotid artery to 25% of the original level. The preparation markedly reduces cerebral edema and induces transient improvements in cerebral circulation.

Key Words

cerebral edema brain ischemia polyethylene oxide 


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  1. 1.
    G. B. Vainshtein and L. E. Pinegin,Fiziol. Zh. SSSR,65, No. 9, 1369–1375 (1980).Google Scholar
  2. 2.
    M. D. Mashkovskii, in:Drugs [in Russian], Vol. 1, Moscow (1993), pp. 586–589.Google Scholar
  3. 3.
    V. V. Natochin and E. I. Shakhmatov,Byull. Eksp. Biol. Med.,69, No. 4, 79–81 (1970).CrossRefGoogle Scholar
  4. 4.
    Methodological Recommendations on the Unification of Examination of Cerebral Circulation [in Russian], Leningrad (1986).Google Scholar
  5. 5.
    V. I. Smol'yakova, in:Proceedings of the Investigations Carried Out by Young Scientists at the Institute of Pharmacology of the Tomsk Scientific Center [in Russian], Tomsk (1995), pp. 36–38.Google Scholar
  6. 6.
    V. M. Cherednichenko and N. S. Pushkar',Oftalmol. Zh., No. 3, 157–159 (1983).Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • M. B. Plotnikov
    • 1
  • V. I. Smol'yakova
    • 1
  • G. A. Chernysheva
    • 1
  1. 1.Institute of PharmacologyScientific Center of the Russian Academy of Medical SciencesTomsk

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