Abstract
Some biochemical mechanisms of the protective effect of cordarone against cardiotoxic activity of strophanthin K are studied in a rat model of circulation insufficiency. The potassium channel blocker and the cardiac glycoside are found to have opposite effects on the lysosome apparatus of the heart.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 407–409, October, 1996
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Galenko-Yaroshevskii, P.A., Lernkina, S.M. & Kostin, Y.V. Correction with cordarone of changes in cathepsin D activity induced by modeled circulation insufficiency and toxic action of strophanthin K. Bull Exp Biol Med 122, 1005–1007 (1996). https://doi.org/10.1007/BF02447021
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DOI: https://doi.org/10.1007/BF02447021