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Morphochemical changes in brain structures and their correction by tuftsin in rats with hypofunction of the dopamine system

  • General Pathology and Pathological Physiology
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Abstract

Chronic administration of haloperidol to Wistar rats induces specific changes in protein metabolism at the cortical-subcortical level (sensorimotor cortex—caudate nucleus), in associative and integrative triggering neurons, and in the cytoplasm and nucleus of the same neuron, judging from the state of structural proteins and aminopeptidase activity. Tuftsin reduces these changes only in the sensorimotor cortex.

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Authors and Affiliations

  1. Institute for Brain Research, Russian Academy of Medical Sciences, Moscow

    L. M. Gershtein, M. T. Dobrynina, A. V. Sergutina & V. I. Rakhmanova

Authors
  1. L. M. Gershtein
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  2. M. T. Dobrynina
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  3. A. V. Sergutina
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  4. V. I. Rakhmanova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 381–383, October, 1996

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Gershtein, L.M., Dobrynina, M.T., Sergutina, A.V. et al. Morphochemical changes in brain structures and their correction by tuftsin in rats with hypofunction of the dopamine system. Bull Exp Biol Med 122, 982–984 (1996). https://doi.org/10.1007/BF02447013

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  • DOI: https://doi.org/10.1007/BF02447013

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