Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 4, pp 979–981 | Cite as

The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation

  • Yu. B. Lishmanov
  • L. N. Maslov
  • E. V. Uskina
  • A. V. Krylatov
General Pathology and Pathological Physiology


Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

Key Words

adaptation arrhythmias μ-and δ-opiate receptors 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Yu. B. Lishmanov
    • 1
  • L. N. Maslov
    • 1
  • E. V. Uskina
    • 1
  • A. V. Krylatov
    • 1
  1. 1.Department of Experimental Cardiology, Institute of CardiologySiberian Division of the Russian Academy of Medical SciencesTomsk

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