Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 4, pp 979–981 | Cite as

The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation

  • Yu. B. Lishmanov
  • L. N. Maslov
  • E. V. Uskina
  • A. V. Krylatov
General Pathology and Pathological Physiology
  • 22 Downloads

Abstract

Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.

Key Words

adaptation arrhythmias μ-and δ-opiate receptors 

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References

  1. 1.
    Yu. B. Lishmanov and L. N. Maslov,Opioid Neuropeptides, Stress, and Adaptive Protection of the Heart [in Russian], Tomsk (1994).Google Scholar
  2. 2.
    Yu. B. Lishmanov, L. N. Maslov, and D. S. Ugdyzhekova,Vestn. Aritmol., No. 3, 48–50 (1994).Google Scholar
  3. 3.
    F. Z. Meerson and M. G. Pshennikova,Adaptation to Stressful Situations and Physical Exercise [in Russian], Moscow (1988).Google Scholar
  4. 4.
    H. Selye,At the Level of the Whole Organism [Russian translation], Moscow (1972).Google Scholar
  5. 5.
    M. Broccardo and G. Improta,Eur. J. Pharmacol.,218, 69–73 (1992).PubMedCrossRefGoogle Scholar
  6. 6.
    D. R. Browen, M. J. Robertson, and L. I. Goldberg,Neuropharmacology,22, No. 3A, 317–321 (1983).CrossRefGoogle Scholar
  7. 7.
    B. K. Handa, A. C. Lane, J. A. H. Lord,et al., Eur. J. Pharmacol.,70, 531–540 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    M. J. Maslov and Yu. B. Lishmanov,Int. J. Cardiol.,40, 89–94 (1993).PubMedCrossRefGoogle Scholar
  9. 9.
    M. J. Millan and F. C. Colpaert,Neuroscience,42, No. 2, 541–553 (1991).PubMedCrossRefGoogle Scholar
  10. 10.
    P. S. Portoghese, M. Sultana, and A. E. Takemori,Eur. J. Pharmacol.,146, 185–186 (1988).PubMedCrossRefGoogle Scholar
  11. 11.
    P. W. Schiller, T. M.-D. Nguyen, N. N. Chung, and C. Lemieux,J. Med. Chem.,32, No. 3, 698–703 (1989).PubMedCrossRefGoogle Scholar
  12. 12.
    C. Ventura, L. Bastagli, P. Bernardi,et al., Biochem. Biophys. Acta,987, 69–74 (1989).PubMedGoogle Scholar
  13. 13.
    E. T. Wei, A. Lee, and J. K. Chang,Life Sci.,26, No. 18, 1517–1522 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Yu. B. Lishmanov
    • 1
  • L. N. Maslov
    • 1
  • E. V. Uskina
    • 1
  • A. V. Krylatov
    • 1
  1. 1.Department of Experimental Cardiology, Institute of CardiologySiberian Division of the Russian Academy of Medical SciencesTomsk

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