The role of central and peripheral μ- and δ-opiate receptors in mediating the antiarrhythmic effect of adaptation
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Adaptation prevents epinephrine-induced arrhythmias in rats, the effect being abolished by naloxone, a μ-receptor antagonist, but not by the δ-receptor antagonist naltrindole. Methylnaltrexone, a blocker of peripheral μ-receptors, weakens the effect of adaptation without eliminating it completely. Central and peripheral μ-receptors may play a key role in the antiarrhythmic effect of adaptation.
Key Wordsadaptation arrhythmias μ-and δ-opiate receptors
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