Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 3, pp 879–881 | Cite as

Effect of antiserotonin antibodies on pain sensitivity in rats with adjuvant-induced arthritis

  • T. V. Davydova
  • V. G. Fomina
  • L. A. Basharova
  • V. A. Evseev
  • S. I. Igon'kina
  • O. I. Mikovskaya
General Pathology and Pathological Physiology
  • 20 Downloads

Abstract

Active immunization with a serotonin—protein conjugate inducing the formation of antiserotonin antibodies exerts an analgesic effect in rats with adjuvant-induced arthritis and inhibits the development of arthritis in early stages after injection of Freund's complete adjuvant.

Key Words

pathological pain adjuvant-induced arthritis serotonin antiserotonin antibodies nociceptors 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    L. A. Basharova, V. A. Evseev, L. A. Vetrile,et al., Byull. Eksp. Biol. Med.,115, No. 5, 469–471 (1993).Google Scholar
  2. 2.
    R. A. Danilova and I. P. Ashmarin,Usp. Fiziol. Nauk,25, No. 1, 3–23 (1994).PubMedGoogle Scholar
  3. 3.
    V. A. Evseev, L. A. Basharova, L. A. Vetrile,et al., Byull. Eksp. Biol. Med.,122, No. 8, 189–192 (1996).Google Scholar
  4. 4.
    V. A. Evseev, T. V. Davydova, V. G. Fomina,et al., ——Ibid.,112, No. 7, 333–334 (1991).Google Scholar
  5. 5.
    V. A. Evseev, T. V. Davydova, V. G. Fomina,et al., ——Ibid.,116, No. 12, 582–584 (1993).Google Scholar
  6. 6.
    V. A. Evseev, N. A. Trekova, L. A. Basharova,et al., ——Ibid.,119, No. 5, 526–529 (1995).CrossRefGoogle Scholar
  7. 7.
    G. J. Birrell, D. S. McQueen, A. Iggo, and B. D. Grubb,Br. J. Pharmacol.,101, 715–721 (1990).PubMedGoogle Scholar
  8. 8.
    H. Ollat, in:Serotonin and Pain, J.-M. Besson (Ed.), New York — Paris — London (1990), pp. 17–30.Google Scholar
  9. 9.
    B. Pescar and S. Spector,Science,480, 1340–1341 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • T. V. Davydova
    • 1
  • V. G. Fomina
    • 1
  • L. A. Basharova
    • 1
  • V. A. Evseev
    • 1
  • S. I. Igon'kina
    • 1
  • O. I. Mikovskaya
    • 1
  1. 1.Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow

Personalised recommendations