Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area
- 23 Downloads
The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout).
Key Wordshippocampus calcium potassium CA1 ion-selective electrodes
Unable to display preview. Download preview PDF.
- 1.V. G. Motin, Yu. A. Tarakanov, G. A. Semkina, and L. V. Kalyuzhnyi,Byull. Eksp. Biol. Med.,113, No. 1, 8–10 (1992).Google Scholar