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Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 3, pp 844–847 | Cite as

Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area

  • V. G. Motin
Physiology
  • 23 Downloads

Abstract

The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout).

Key Words

hippocampus calcium potassium CA1 ion-selective electrodes 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • V. G. Motin
    • 1
  1. 1.P. K. Anokhin institute of Nornal PhysiologyRussian Academy of Medical SciencesMoscow

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