Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area
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The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout).
Key Wordshippocampus calcium potassium CA1 ion-selective electrodes
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