Abstract
The paper describes a method of quantifying Duchenne muscular dystrophy which is examiner independent and uses surface electromyographic signals (EMG). A standardised protocol is proposed. Spectral parameters are first computed from digitised EMG, then a polynomial model is deduced from the evolution of each parameter. A discriminant analysis between healthy and DMD subjects leads to the determination of a discriminant plane and a level of sickness index.
Similar content being viewed by others
References
Brooke, M. H., Griggs, R. C., Mendell, J. R., Fenichel, G. M., Shumate, J. B. andPellegrino, R. J. (1981) Climical trial in Duchenne dystrophy. 1: The design of the protocol.Muscle & Nerve,4, 186–197.
Brooke, M. H., Fenichel, G. M., Griggs, R. C., Mendell, J. R., Moxley, R., Miller, P., Province, M. A. and the CIDD Group (1983) Clinical investigation in Duchenne dystrophy: 2. Determination of the ‘power’ of therapeutic trials based on the natural history.,6, 91–103.
Brooke, M. H., Fenichel, G. M., Griggs, R. C., Mendell, J. R., Moxley, R. T., Miller, J. P., Kaiser, K. K., Florence, J. M., Pandya, S., Signore, L., King, W., Robison, J., Head, R. A., Province, M. A., Seyfried, W. andMandell, S. (1987) Clinical investigation in Duchenne muscular dystrophy: interesting results in a trial of prednisone.Arch. Neurol.,44, 812–817.
Burke, R. E., Levine, D. N., Tsairis, P. andZajac, F. E. (1973) Physiological types and histochemical profiles in motor units of the cat gastrocnemius.J. Physiol., London,234, 723–748.
De Luca, C. J. (1984) Myoelectrical manifestations of localized muscular fatigue in humans.Crit. Rev. in Biomed. Eng.,11, 251–279.
Den Dunnen, J. T., Bakker, E., Klein-Breteler, E. G., Pearson, P. L. andvan Ommen, G. J. B. (1987) Direct detection of more than 50% of the Duchenne muscular dystrophy mutations by field inversion gels.Nature,329, 640–642.
Dubowitz, V. andBrooke, M. H. (1973)Muscle biopsy: a modern approach. Saunders, Philadelphia.
Duchene, J. andGoubel, F. (1982) Muscular fatiguability of an heterogeneous muscular group. 5th Congr. Int. Soc. Electrophysiol. Kinesiol., Ljubljana; inZdrv. Vestn,51, Suppl. 1, 212–213.
Duchene, J. (1985) The Δ-transform.Patt. Recog. Lett.,3, 149–154.
Duchenne de Boulogne, G. B. (1867)Physiologie des mouvements. J.-B. Baillière, Paris.
Florence, J. M., Pandya, S., King, W. M. et al. (1982) Clinical trials in Duchenne dystrophy: standardization reliability of evaluation procedures.Phys. Ther.,62, 661–662.
Goldstein, R. L., Hyde, R. W., Lapham, L. W., Gazroglu, K. andDepapp, Z. G. (1974) Peripheral neuropathy presenting with respiratory insufficiency as a primary complaint: problems of recognizing alveolar hypoventilation due to neuromuscular disorders.Am. J. Med.,56, 443–469.
Hagberg, M. andEricson, B. E. (1982) Myoelectric power spectrum dependence on muscular contraction level of elbow flexors.Eur. J. Appl. Physiol.,48, 147–156.
Iddings, M. D., Smith, L. K. andSpencer, W. A. (1961) Muscle testing: Part 2, Reliability in clinical use.Phys. Ther.,41, 249–256.
Legrand-Persoz, M., Persoz, B. andArhan, P. (1977) Evolution de la force musculaire et du taux de creatine phosphokinase sérique dans la maladie de Duchenne de Boulogne à évolution rapide.Ann. de. Méd. Physique,T.XX, (1), 1–8.
Lilenfield, A. M., Jacobs, M. andMagnusson, R. (1954) Study of the reproducibility of muscle testing and certain other aspects of muscle scoring.Phys. Ther.,34, 279–290.
Lindström, L., Kadefors, R. andPetersen, I. (1977) An electromyographic index for localized muscle fatigue.J. Appl. Physiol.,43, 750–754.
Lindström, L. andPetersen, I. (1983) Power spectrum analysis of EMG signals and its applications. InComputer-aided electromyography. Karger, Basel, 1–51.
Mendell, J. R., Province, M. A., Moxley, R. T. III, Griggs, R. C., Brooke, M. H., Fenichel, G. M., Miller, J. P., Kaiser, K. K., King, W. M., Robison, J., Signore, L., Pandya, S., Florence, J. M., Seyfried, W. andMandel, S. (1987) Clinical investigation of Duchenne muscular dystrophy: a methodology for therapeutic trials based on natural history controls.Arch. Neurol.,44, 808–811.
Milner-Brown, H. S., Mellenthin, M. andMiller, R. G. (1986) Quantifying human muscle strength, endurance and fatigue.Arch. Phys. Med. Rehabil.,67, 530–535.
Scott, O. M., Hyde, S. A., Goddard, C. andDubowitz, V. (1982) Quantitation of muscle function in children: a prospective study in Duchenne muscular dystrophy.,5, 291–310.
Späth, H. (1980)Cluster analysis algorithms: for data reduction and classification of objects. Wiley, New York.
Stern, L. M., Fewings, J. D., Bretag, A. H., Ballard, F. J., Thomas, F. M., Cooper, D. M. andGoldblatt, E. (1981) The progression of Duchenne muscular dystrophy: clinical trial of allopurinol therapy.Neurol.,31, 422–426.
Stulen, F. B. andDe Luca, C. J. (1981) Frequency parameters of the myoelectric signal as a measure of muscle conduction velocity.IEEE Trans.,BME-28, 515–523.
Vignos, P. I., Spencer, G. andArchibald, K. (1963) Management of progressive muscular dystrophy of childhood.JAMA,184, 89–110.
Webster, C., Silberstein, L., Hays, A. P. andBlau, H. M. (1988) Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy.Cell,52, 503–513.
Ziter, F. A., Allstop, K. G. andTyler, F. H. (1977) Assessment of muscle strength in Duchenne muscular dystrophy.Neurology,27, 981–984.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Priez, A., Duchene, J. & Goubel, F. Duchenne muscular dystrophy quantification: a multivariate analysis of surface EMG. Med. Biol. Eng. Comput. 30, 283–291 (1992). https://doi.org/10.1007/BF02446966
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02446966