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Ultrastructural changes in albino mouse liver caused by isogenous F1+ and F1− strains ofYersinia pestis and their correction with ceftriaxone

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Fatty dystrophy and partial cytoplasmic necrosis predominate during the preagonal period in parenchymatous organs of mice infected withYersinia pestis 231 F1+. Endothelial damage, fibrin precipitation, and microcirculatory disorders occur in sinusoidal capillaries. More pronounced changes in the liver develop during the preagonal period in mice infected withY. pestis 231 F1−. Treatment with ceftriaxone leads to 100% survival in both groups and substantial restoration of liver structure.

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Authors and Affiliations

  1. Laboratory of Pathomorphology, Laboratory for the Prevention and Treatment of Plague, Institute of Plague, Rostov-on-Don

    E. A. Bardakhch'yan, I. V. Ryzhko, V. V. Pasyukov & E. D. Samokhodkina

Authors
  1. E. A. Bardakhch'yan
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  2. I. V. Ryzhko
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  3. V. V. Pasyukov
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  4. E. D. Samokhodkina
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 589–593, May, 1996

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Bardakhch'yan, E.A., Ryzhko, I.V., Pasyukov, V.V. et al. Ultrastructural changes in albino mouse liver caused by isogenous F1+ and F1− strains ofYersinia pestis and their correction with ceftriaxone. Bull Exp Biol Med 121, 533–536 (1996). https://doi.org/10.1007/BF02446960

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  • DOI: https://doi.org/10.1007/BF02446960

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