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Effect of dioxydine and cyclophosphane on lipid peroxidation and superoxide dismutase and catalase activities in C57Bl/6 and BALB/c mice

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Twenty-four hours after intraperitoneal injection of cyclophosphane (40 mg/kg) and dioxydine (300 mg/kg) to C57Bl/6 mice, liver catalase activity dropped by 29 and 23%, respectively. In BALB/c mice, dioxydine (but not cyclophosphane) reduced catalase activity by 24%. Superoxide dismutase activity was lowered by cyclophosphane (but not dioxydine) in BALB/c mice, and by both dioxydine and cyclophosphane in C57Bl/6 mice (by 24 and 86%, respectively). The level of 2-thiobarbituric acid (TBA)-reactive lipid peroxidation (LPO) products in the liver of BALB/c mice treated with cyclophosphane and dioxydine increased 1.4- and 2.1-fold, respectively, while in C57Bl/6 mice it did not differ from the control. The initial rate ofin vitro-induced LPO in BALB/c mice receiving cyclophosphane and dioxydine increased 1.5- and 4-fold, respectively. In C57Bl/6 mice both cyclophosphane and dioxydine inhibited the accumulation of TBA-reactive LPO products. On the whole, animals of the C57Bl/6 strain are more resistant to the LPO-inducing action of mutagens than BALB/c mice, despite the fact that the latter are characterized by a higher activity of antioxidant enzymes.

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 528–532, May, 1996

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Durnev, A.D., Sazontova, T.G., Guseva, N.V. et al. Effect of dioxydine and cyclophosphane on lipid peroxidation and superoxide dismutase and catalase activities in C57Bl/6 and BALB/c mice. Bull Exp Biol Med 121, 478–481 (1996). https://doi.org/10.1007/BF02446942

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  • DOI: https://doi.org/10.1007/BF02446942

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