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Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 2, pp 820–822 | Cite as

Activity and inducibility of cytochrome P-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene

  • L. F. Gulyaeva
  • L. Yu. Zakharova
  • V. V. Lyakhorich
  • T. S. Morozkova
  • V. I. Kaledin
Oncology
  • 21 Downloads

Abstract

Specific activity of cytochrome P-450-1a is detected in the liver of 7 inbred mouse strains sensitive (SWR, C3HA, DD, and CBA) and resistant (AKR, CC57BR, and C57BL) to o-aminoazotoluene-induced hepatocarcinogenesis: 7-ethoxyresorufin-O-diethylase and 7-methoxyresorufin-O-dimethylase, induced by benzo(a)pyrene and o-aminoazotoluene. Mice sensitive (CC57BR and C57BL) and resistant (AKR) to P-450-1a induction were resistant to induction of liver tumor and, similarly, mice both resistant (SWR and DD) and sensitive (C3HA and CBA) to P-450-1a induction were sensitive to hepatic tumor induction. Therefore, there was no correlation between inducibility of cytochrome P-450-1a and sensitivity to o-aminoazotoluene-induced hepatocarcinogenesis at the initial stages of chemical carcinogenesis.

Key Words

inbred mice o-aminoazotoluene induction cytochrome P-450-1a 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • L. F. Gulyaeva
    • 1
  • L. Yu. Zakharova
    • 1
  • V. V. Lyakhorich
    • 1
  • T. S. Morozkova
    • 2
  • V. I. Kaledin
    • 2
  1. 1.Institute of Molecular Pathology and Ecological BiochemistrySiberian Division of Russian Academy of Medical SciencesNovosibirsk
  2. 2.Institute of Cytology and GeneticsSiberian Division of Russian Academy of SciencesNovosibirsk

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