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Effect of trekrezan on lipid peroxidation in patients with chronic heart failure

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of the new Russian-manufactured immunomodulator trekrezan in combination with isosorbide dinitrate on lipid peroxidation is studied in patients with chronic heart failure associated with ischemic heart disease, arterial hypertension, and dilated cardiomyopathy. Trekrezan reduces blood content of malonic dialdehyde and diene conjugates and the index of peroxide production and increases the content of vitamin A. Trekrezan can be recommended for clinical use.

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Authors and Affiliations

  1. Russian Research Center, Institute of Chemistry and Technology of Heteroorganic Compounds, I. Ya. Gorbachevskii Medical Institute, Temopol

    R. O. Sabadyshin, O. Ya. Slipak, S. F. Koval'chuk, V. M. D'yakov & V. B. Kazimirovskaya

Authors
  1. R. O. Sabadyshin
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  2. O. Ya. Slipak
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  3. S. F. Koval'chuk
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  4. V. M. D'yakov
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  5. V. B. Kazimirovskaya
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 186–188, August, 1998

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Sabadyshin, R.O., Slipak, O.Y., Koval'chuk, S.F. et al. Effect of trekrezan on lipid peroxidation in patients with chronic heart failure. Bull Exp Biol Med 126, 807–809 (1998). https://doi.org/10.1007/BF02446916

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  • DOI: https://doi.org/10.1007/BF02446916

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