Abstract
Membrane expression of β2 Mac-I, urokinase receptors, and membrane-bound urokinase on peripheral blood monocytes is studied in healthy donors and patients with stable angina pectoris. Spontaneous, formylpeptide- and urokinase-induced monocyte migration is assessed. Monocytes from patients are characterized by a higher content of membrane-bound urokinase. In contrast to peripheral blood monocytes from healthy donors, exogenous urokinase does not enhance migration of monocytes from patients with angina.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 147–149, August, 1998
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Aref'eva, T.I., Krasnikova, T.L., Parfenova, E.V. et al. Accumulation of membrane-bound urokinase on monocytes in atherosclerotic patients is accompanied by suppression of urokinase-induced monocyte migration. Bull Exp Biol Med 126, 772–774 (1998). https://doi.org/10.1007/BF02446905
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DOI: https://doi.org/10.1007/BF02446905