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The use of perfluorinated emulsion for prolongation of the endurance period in lethal hypoxia

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Abstract

The apnea model with venovenous perfusion and blood oxygenation in a membrane oxygenator was used to study the gas transport characteristics of perfluorinated emulsion with the aim to prolong the endurance period in lethal hypoxia. The use of PFOS emulsion (40 ml/kg) as a hemodilution agent at relatively low rate of assisted perfusion (35 ml/kg×min) produced no improvement of oxygen supply during the critical period in comparison with conventional plasma substitutes. However, perfusion with oxygenated perfluorinated emulsion prolonged survival as compared with polyglucin perfusion, mainly due to the maintenance of the vitally important organs (heart and brain) and due to the improvement of microcirculation.

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Authors and Affiliations

  1. P. A. Kupriyanov Cardiovascular Surgery Clinics, Military Medical Academy, St. Petersburg

    V. I. Skorik, V. V. Shilov, A. V. Sudus & V. V. Zuev

Authors
  1. V. I. Skorik
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  2. V. V. Shilov
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  3. A. V. Sudus
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  4. V. V. Zuev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 477–480, October, 1997

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Skorik, V.I., Shilov, V.V., Sudus, A.V. et al. The use of perfluorinated emulsion for prolongation of the endurance period in lethal hypoxia. Bull Exp Biol Med 124, 1042–1045 (1997). https://doi.org/10.1007/BF02446856

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  • DOI: https://doi.org/10.1007/BF02446856

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