Skip to main content
SpringerLink
Log in

Response of the middle cerebral artery to serotonin

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of serotonin on blood flow in the middle cerebral and common carotid arteries was studied with the help of Doppler ultrasonography on Wistar rats under general anesthesia. Serotonin induced a constrictor-dilator reaction in the middle cerebral artery: in 50% of experiments a marked initial blood flow drop was followed by a moderate increase, and then again by a profound and long decrease of the blood flow. At the same time the blood flow augmented in the common carotid artery. The data show selective and mostly vasoconstrictor effect of serotonin of the middle cerebral artery system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. D. Matsievskii, L. M. Bellina, and E. A. Tolmacheva,Byull. Eksp. Biol. Med.,114, No. 7, 19–22 (1992).

    CAS  Google Scholar 

  2. D. D. Matsievskii, O. S. Medvedev, E. V. Oranovskaya,et al., ——Ibid.,106, No. 12, 674–676 (1988).

    CAS  Google Scholar 

  3. M. D. Mashkovskii and V. P. Lanskii, ——Ibid.,64, No. 11, 95–99 (1967).

    Google Scholar 

  4. R. S. Mirzoyan, D. D. Matsievskii, and G. A. Semkina, ——Ibid.,118, No. 10, 410–413 (1994).

    CAS  Google Scholar 

  5. R. S. Mirzoyan, N. A. Romanycheva, T. S. Gan'shina,et al., Eksp. Klin. Farmakol.,56, No. 3, 22–25 (1993).

    CAS  Google Scholar 

  6. L. Edvinsson, A. Degulurce, E. T. MacKenzie,et al., in:L. E. R. S., Vol. 2, New York (1984), pp. 121–137.

  7. L. Edvinsson, I. E. Hardebo, and C. Owman,Circ. Res.,42, 143–151 (1978).

    PubMed  CAS  Google Scholar 

  8. A. M. Harper and E. T. MacKenzie,J. Physiol. (Lond.),271, 735–746 (1977).

    CAS  Google Scholar 

  9. I. W. Lance,Eur. Neurol.,31, 279–281 (1991).

    PubMed  CAS  Google Scholar 

  10. D. D. Matsievskii, R. S. Mirzoyan, N. Ya. Kovalenko,et al., Pharmacology,31, Suppl., 377 (1995).

    Google Scholar 

  11. F. T. Nicholls, M. Mawad, I. P. Mohr,et al., Stroke,21, 555–559 (1990).

    Google Scholar 

  12. I. M. van Nueten, W. I. Ganssers, and P. M. Vanhoutte,Pharmacol. Res. Commun.,17, No. 7, 585–608 (1985).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    R. S. Mirzoyan, G. A. Semkina & D. D. Matsievskii

  2. Laboratory of Bioengineering, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    R. S. Mirzoyan, G. A. Semkina & D. D. Matsievskii

Authors
  1. R. S. Mirzoyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. Semkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. D. Matsievskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 417–420, October, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mirzoyan, R.S., Semkina, G.A. & Matsievskii, D.D. Response of the middle cerebral artery to serotonin. Bull Exp Biol Med 124, 988–991 (1997). https://doi.org/10.1007/BF02446841

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02446841

Key Words

Search

Navigation