Energy metabolism disturbances induced by multiple ischemic preconditioning worsen the recovery of cardiac function in reperfusion
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Single ischemic preconditioning improves functional recovery of isolated rat heart subjected to global ischemia and reperfusion. Two preconditioning cycles abolish this protective effect, while 4 cycles impair functional recovery of the heart. These phenomena are due to the fact that repetitive ischemic preconditioning reduces the content of phosphocreatine and adenine nucleotides in the heart before long-term ischemia, which prevents the recovery of energy metabolism and induces additional damage to cardiomyocyte membranes during reperfusion.
Key Wordsrat heart preconditioning pump function energy metabolism
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