Abstract
Burst stimulation of the vagus nerve in cats results in synchronization of vagal and cardiac rhythms, while their desynchronization leads to sinus arrhythmia. Using a coefficient characterizing the magnitude of chronotropic effect, we have determined a zone of cardiocycle where the stimulating effect of the vagus stimulus was several times higher than in other zones. Somatostatin reduces this zone and increases the range of theP-P interval fluctuations in it, while somatostatin antagonist has an opposite effects. The observed phenomenon can underlie the potentiating effect of somatostatin on the dynamics of controlled vagal bradycardia.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 372–376, October, 1997
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Osadchii, O.E., Pokrovskii, V.M. & Matsko, M.A. Mechanism of vagotropic effect of somatostatin. Bull Exp Biol Med 124, 948–951 (1997). https://doi.org/10.1007/BF02446829
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DOI: https://doi.org/10.1007/BF02446829