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Repopulation of the liver after dipin-induced damage

  • I. V. Uryvaeva
Reviews

Abstract

The alkylating preparation dipin in combination with partial hepatectomy induces genomic damage and apoptosis of hepatocytes with total replacement of parenchyma at the expense of the stem reserve cells. This model was employed to study the responses of the cell cycle to genetic damage, mechanisms of cell survival and death, and the sources of cells repopulating liver parenchyma.

Key Words

liver dipin genome damage apoptosis stem cells 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • I. V. Uryvaeva
    • 1
  1. 1.Laboratory of Cytology, N. K. Kol'tsov Institute of Developmental BiologyRussian Academy of SciencesMoscow

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