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Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 3, pp 325–326 | Cite as

Selection of anxious mice by a three-stage test in an elevated T-maze

  • I. P. Lapin
  • S. M. Mirzaev
Methods

Abstract

Daily testing of SHR and C57Bl/6 mice during 3 days shows an increase of the number of mice with a high level of anxiety, which was determined according to the ratio of the number of entries into the light arms to the total sum of entries into the light and dark arms of an elevated T-maze. Such results were obtained after 3 testings every 3 days in C57Bl/6 but not in SHR mice. This procedure is proposed for the selection of anxious individuals as objects for an anxiety model.

Key Words

anxiety mice selection elevated T-maze 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • I. P. Lapin
    • 1
  • S. M. Mirzaev
    • 1
  1. 1.V. M. Bekhterev Psychoneurological InstituteSt. Petersburg

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