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The mechanism of pulmonary hypertension in rats with high-altitude hypoxia

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Morphofunctional examinations of the lungs of rats exposed to high-altitude conditions for 3 to 300 days revealed that systolic pulmonary hypertension observed during the entire period of study is caused by a total increase of the elastic resistance of pulmonary arteries. Adequate bloodflow in such a case is provided by intensive work of the right-ventricular myocardium against this resistance.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    B. I. Mazhbich, L. M. Nepomnyashchikh & E. L. Lushnikova

  2. Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    B. I. Mazhbich, L. M. Nepomnyashchikh & E. L. Lushnikova

Authors
  1. B. I. Mazhbich
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  2. L. M. Nepomnyashchikh
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  3. E. L. Lushnikova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 324–327, March, 1996

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Mazhbich, B.I., Nepomnyashchikh, L.M. & Lushnikova, E.L. The mechanism of pulmonary hypertension in rats with high-altitude hypoxia. Bull Exp Biol Med 121, 296–299 (1996). https://doi.org/10.1007/BF02446776

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  • DOI: https://doi.org/10.1007/BF02446776

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