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Effect of nimodipine on cell calcium concentration and platelet aggregation in patients with ischemic stroke

  • Experimental Methods for Clinical Practice
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The rate of spontaneous platelet aggregation is 1.5-2-fold increased in patients with ischemic stroke in comparison with control values. Monotherapy with nimodipine lowers parameters of spontaneous platelet aggregation virtually to normal values. Nimodipine inhibits ADP-induced aggregation but does not affect the ADP affinity of platelet receptors. Experiments with a Fura 2-AM fluorescent probe show that the basal calcium level in platelets from patients with ischemic stroke reliably surpassed that in healthy donors. Nimodipine inhibits the ADP-induced rise of the cell calcium level.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Department of Neurology and Neurosurgery No. 2, Russian State Medical University, Moscow

    N. A. Pryanikova, A. S. Dukhanin, L. V. Stakhovskaya & N. S. Chekneva

Authors
  1. N. A. Pryanikova
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  2. A. S. Dukhanin
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  3. L. V. Stakhovskaya
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  4. N. S. Chekneva
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny Vol. 121, No 3, pp. 317–320, March, 1996

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Pryanikova, N.A., Dukhanin, A.S., Stakhovskaya, L.V. et al. Effect of nimodipine on cell calcium concentration and platelet aggregation in patients with ischemic stroke. Bull Exp Biol Med 121, 291–293 (1996). https://doi.org/10.1007/BF02446774

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  • DOI: https://doi.org/10.1007/BF02446774

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