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The content of tocopherol and lipid peroxidation products in the tissues of rats with genetically determined hyperproduction of free oxygen radicals

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that at the age of 2–3 months S rats with genetically determined hyperproduction of free radicals have the same content of tocopherol in the heart, epididymal fat, adrenals, liver, and liver mitochondria as Wistar rats but a lower content of plasma tocopherol. At 10–12 months, the tocopherol content in all studied tissues and organs, except the liver, is higher than in young S rats and age-matched Wistar rats. This is regarded as a compensatory response facilitating the stabilization of LPO under conditions of increased free radical formation.

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Authors and Affiliations

  1. Institute of Biochemistry and Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    N. G. Kolosova, N. A. Solov'eva, I. G. Shabalina & R. I. Salganik

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    N. G. Kolosova, N. A. Solov'eva, I. G. Shabalina & R. I. Salganik

Authors
  1. N. G. Kolosova
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  2. N. A. Solov'eva
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  3. I. G. Shabalina
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  4. R. I. Salganik
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 282–284, March, 1996

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Kolosova, N.G., Solov'eva, N.A., Shabalina, I.G. et al. The content of tocopherol and lipid peroxidation products in the tissues of rats with genetically determined hyperproduction of free oxygen radicals. Bull Exp Biol Med 121, 259–261 (1996). https://doi.org/10.1007/BF02446763

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  • DOI: https://doi.org/10.1007/BF02446763

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