Abstract
Administration of etimyzol in a dose of 4 mg/kg to rats with deafferentation pain syndrome reduces the incidence of the syndrome and its severity. This effect is associated with activation of the hypothalamic-hypophyseal-adrenal system. Systematic administration of the preparation models repeated stress, thus developing adaptation.
Similar content being viewed by others
References
M. P. Gorizontova,Vest. Akad. Med. Nauk SSSR, No 2, 44–51 (1988).
M. P. Gorizontova, O. V. Alekseev, and A. M. Chernukh,Byull. Eksp. Biol. Med.,79, No 3, 22–25 (1975).
M. P. Gorizontova and I. V. Mironova, —Ibid.,115, No 3, 233–236 (1993).
G. N. Kryzhanovskii, V. K. Reshetnyak, M. L. Kukushkin,et al., Pat. Fiziol., No 6, 8–10 (1991).
F. Z. Meerson,Adaptation, Stress, and Prevention [in Russian], Moscow (1981).
I. V. Mironova, M. P. Gorizontova, and V. K. Reshetnyak,Byull. Eksp. Biol. Med.,117, No 3, 235–237 (1994).
A. V. Osipov and M. L. Kukushkin, —Ibid.,115, No 5, 471–473 (1993).
V. E. Ryzhenkov, in:Etimyzol [in Russian], Leningrad (1972), pp. 16–19.
N. S. Sapronov,Farmakol. Toksikol.,42, No 3, 216–221 (1979).
F. V. Abbot, K. B. Y. Franklin, and B. Connel,Eur. J. Pharmacol.,126, 141–144 (1986).
T. Kauppila and A. Petrovaara,Exp. Neurol.,111, No 1 128–130 (1991).
Z. Seltzer, M. Tal, and Y. Sharav,Pain,37, No 2, 245–250 (1989).
Z. Wiesenfeld and R. G. Hallin,Physiol. Behav.,27, No 4, 735–740 (1981).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3 pp. 258–261, March, 1996
Rights and permissions
About this article
Cite this article
Gorizontova, M.P., Mironova, I.V. & Reshetnyak, V.K. The effect of etimyzol on the development of the deafferentation pain syndrome. Bull Exp Biol Med 121, 237–240 (1996). https://doi.org/10.1007/BF02446756
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02446756