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Effects of adaptation to periodic hypoxia on kinetic parameters of respiratory chain enzymes in rat brain

  • General Pathology and Pathologycal Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A study of kinetic parameters of brain respiratory enzymes revealed that the maximal velocity and the Michaelis apparent constant for NADH-cytochrome C-reductase are significantly lower in low-resistant rats than in rats with a high resistance to hypoxia. Adaptation to periodic hypoxia increases total resistance only in low-resistant rats. It is accompanied by an increase in the values of kinetics parameters for NADH-cytochrome C-reductase and cytochrome oxidase. Kinetic parameters for these enzymes in the brain of high-resistant rats are either unaltered or even decreased. It is suggested that the first enzymatic complex of the respiratory chain is one of the limiting or regulating links in energy metabolism determining the brain's resistance to hypoxia.

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Authors and Affiliations

  1. Laboratory of Bioenergetics, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    A. M. Dudchenko & L. D. Luk'yanova

Authors
  1. A. M. Dudchenko
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  2. L. D. Luk'yanova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 252–255, March, 1996.

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Dudchenko, A.M., Luk'yanova, L.D. Effects of adaptation to periodic hypoxia on kinetic parameters of respiratory chain enzymes in rat brain. Bull Exp Biol Med 121, 232–235 (1996). https://doi.org/10.1007/BF02446754

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  • DOI: https://doi.org/10.1007/BF02446754

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