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Anticarcinogenic effect of beta carotene on the development of renal tumors in rats induced by 3-(αL-arabinopyranosyl-1) methyl-1-nitrosourea (AMNU)

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of beta carotene on AMNU-induced carcinogenesis was studied in rats. Administration of beta carotene reliably decreased both the total incidence of tumors and the incidence of renal tumors. The results are an experimental validation of the possibility of using beta carotene to lower the risk of second primary malignancies during the treatment of cancer patients with nitrosoalkylurea drugs.

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Authors and Affiliations

  1. Research Institute of Experimental Diagnosis and Therapy of Tumors, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    N. I. Sherenesheva, V. E. Fin'ko & T. I. Klochkova

Authors
  1. N. I. Sherenesheva
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  2. V. E. Fin'ko
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  3. T. I. Klochkova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 453–455, April, 1996

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Sherenesheva, N.I., Fin'ko, V.E. & Klochkova, T.I. Anticarcinogenic effect of beta carotene on the development of renal tumors in rats induced by 3-(αL-arabinopyranosyl-1) methyl-1-nitrosourea (AMNU). Bull Exp Biol Med 121, 413–415 (1996). https://doi.org/10.1007/BF02446744

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  • DOI: https://doi.org/10.1007/BF02446744

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