Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels
In vitro experiments demonstrate the high affinity of the toxic convulsant norbornan [2,2-di-(trifluoromethyl)-3,3-dicyano-5,6-dichloronorbornane] for the GABAA-receptor chloride channels of membranes from rat brain. Repeated washing and centrifugation do not restore the ionophore density on norbornan-treated membranes, suggesting that norbornan may be counted among the agents acylating the chloride channels.
Key Wordsnorbornan GABAAreceptors chloride ionophore GABAlytics acylation
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