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Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 4, pp 404–406 | Cite as

Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels

  • A. I. Golovko
  • G. A. Sofronov
  • T. V. Klyuntina
Pharmacology and Toxicology

Abstract

In vitro experiments demonstrate the high affinity of the toxic convulsant norbornan [2,2-di-(trifluoromethyl)-3,3-dicyano-5,6-dichloronorbornane] for the GABAA-receptor chloride channels of membranes from rat brain. Repeated washing and centrifugation do not restore the ionophore density on norbornan-treated membranes, suggesting that norbornan may be counted among the agents acylating the chloride channels.

Key Words

norbornan GABAAreceptors chloride ionophore GABAlytics acylation 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. I. Golovko
    • 1
  • G. A. Sofronov
    • 1
  • T. V. Klyuntina
    • 1
  1. 1.Military Medical AcademySt. Petersburg

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