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Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vitro experiments demonstrate the high affinity of the toxic convulsant norbornan [2,2-di-(trifluoromethyl)-3,3-dicyano-5,6-dichloronorbornane] for the GABAA-receptor chloride channels of membranes from rat brain. Repeated washing and centrifugation do not restore the ionophore density on norbornan-treated membranes, suggesting that norbornan may be counted among the agents acylating the chloride channels.

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Authors and Affiliations

  1. Military Medical Academy, St. Petersburg

    A. I. Golovko, G. A. Sofronov & T. V. Klyuntina

Authors
  1. A. I. Golovko
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  2. G. A. Sofronov
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  3. T. V. Klyuntina
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 444–446, April, 1996

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Golovko, A.I., Sofronov, G.A. & Klyuntina, T.V. Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels. Bull Exp Biol Med 121, 404–406 (1996). https://doi.org/10.1007/BF02446741

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  • DOI: https://doi.org/10.1007/BF02446741

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