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Dopamine autoreceptors of subtype D3 regulate mainly dopamine release in the basal ganglia of rat brain

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

By means of intracerebral microdialysis it is shown that a selective agonist of the dopamine D3 receptors, 7-hydroxy-N,N-di-n-propyl-2-aminotetralin, causes a dose-dependent decrease of dopamine release but not its synthesis, which confirms the preeminent involvement of D3 dopamine autoreceptors in presynaptic regulation of the release of this transmitter in the basal ganglia of rat brain.

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References

  1. R. R. Gainetdinov, T. D. Sotnikova, T. V. Grekhova, and K. S. Raevskii,Dokl. Rossiisk. Akad. Nauk,337, No. 6, 821–823 (1994).

    CAS  Google Scholar 

  2. A. Carlsson, in:Pre- and Postsynaptic Receptors, E. Usdinet al., eds., New York (1975), pp. 49–63.

  3. R. R. Gainetdinov, M. B. Bogdanov, V. S. Kudrin, and K. S. Rayevsky,Neuropharmacology,33, 215–219 (1994).

    Article  Google Scholar 

  4. R. R. Gainetdinov, T. V. Grekhova, T. D. Sotnikova, and K. S. Rayevsky,Eur. J. Pharmacol.,261, 327–331 (1994).

    Article  PubMed  CAS  Google Scholar 

  5. R. R. Gainetdinov, T. D. Sotnikova, T. V. Grekhova, and K. S. Rayevsky,Soc. Neurosci. Abstr.,20, 1355 (1994).

    Google Scholar 

  6. J. A. Gingrich and M. G. Caron,Annu. Rev. Neurosci.,16, 299–321 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. E. Gurevich, M.-P. Kung, H. Kung, and J. N. Joyce,Soc. Neurosci. Abstr.,20, 1169 (1994).

    Google Scholar 

  8. D. Levesque, J. Diaz, C. Pilon,et al., Proc. Natl. Acad. Sci. USA,89, 8155–8159 (1992).

    Article  PubMed  CAS  Google Scholar 

  9. K. S. Rayevsky, R. R. Gainetdinov, T. V. Grekhova,et al., Soc. Neurosci. Abstr.,19, 1065 (1993).

    Google Scholar 

  10. P. Sokoloff, B. Giros, M.-P. Martres,et al., Nature,347, 146–151 (1990).

    Article  PubMed  CAS  Google Scholar 

  11. L. Stahle, in:Microdialysis in Neuroscience, T. E. Robinsonet al., eds., Amsterdam (1991), pp. 155–174.

  12. K. Svensson, A. Carlsson, R. M. Huff,et al., Eur. J. Pharmacol.,263, 235–243 (1994).

    Article  PubMed  CAS  Google Scholar 

  13. S. Yamada, H. Yokoo, and S. Nishi,Brain Res.,648, 176–179 (1994).

    Article  PubMed  CAS  Google Scholar 

  14. N. Waters, S. Lagerkvist, L. Lofberg,et al., Eur. J. Pharmacol.,242, 151–163 (1993).

    Article  PubMed  CAS  Google Scholar 

  15. B. H. C. Westerink, J. B. De Vries, and R. Duran,J. Neurochem.,54, 381–387 (1990).

    PubMed  CAS  Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 430–434, April, 1996

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Sotnikova, T.D., Gainetdinov, R.R., Grekhova, T.V. et al. Dopamine autoreceptors of subtype D3 regulate mainly dopamine release in the basal ganglia of rat brain. Bull Exp Biol Med 121, 392–396 (1996). https://doi.org/10.1007/BF02446737

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  • DOI: https://doi.org/10.1007/BF02446737

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