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Antineurotic effect of the hydrazide of O-β-chlorethyl-para-N-dimethylaminophenyl-phosphinylacetic acid (amphasid)

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

An novel organophosphorus compound, the hydrazide of O-β-chlorethyl-para-N-dimethylaminophenyl-phosphinylacetic acid (amphasid), was found to be an antineurotic agent. Amphasid restored exploratory activity in rats according to the open field test in experimental neurosis, raised the brain level of RNA and DNA lowered by stress, and reduced the concentration of malonic dialdehyde in the brain cortex of neurotized rats.

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References

  1. N. A. Blyukherova, in:Pharmacology and Toxicology of Organophosphorus Compounds and Other Biologically Active Substances. Transactions of Kazan Medical Institute [in Russian], Kazan (1974), pp. 118–122.

  2. A. V. Val'dman and Yu. A. Aleksandrovskii,Psychopharmacotherapy of Neurotic Disorders [in Russian], Moscow (1987).

  3. A. V. Val'dman, M. M. Kozlovskaya, I. V. Zaikonnikova,et al., Byull. Eksp. Biol. Med.,89, No. 3, 310–312 (1980).

    Article  Google Scholar 

  4. I. V. Zaikonnikova, A. V. Val'dman, M. M. Kozlovskaya, and G. F. Rzhevskaya,Farmakol. Toksicol., No. 3, 334–338 (1980).

    Google Scholar 

  5. V. E. Kolla and I. S. Berdinskii,Pharmacology and Chemistry of Hydrazine Derivatives [in Russian], Ioshkar-Ola (1976).

  6. D. E. C. Corbridge,Phosphorus. Bases for Chemistry, Biochemistry, and Technology, Amsterdam (1980).

  7. I. D. Stal'naya and T. G. Garshvili,Modern Methods in Biochemistry [in Russian], Moscow (1977).

  8. R. R. Tsanev and G. O. Markov,Biochemistry,25, 151–159 (1960).

    CAS  Google Scholar 

  9. K. Hecht, A. Mechedova, K. Treptov, and T. Hecht,Acta Biol. Med. Germ., No. 8, 867–879 (1976).

    Google Scholar 

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Authors and Affiliations

  1. Kazan State Medical University, Kazan, USSR

    I. I. Semina, A. Z. Baichurina & R. S. Garaev

Authors
  1. I. I. Semina
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  2. A. Z. Baichurina
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  3. R. S. Garaev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 423–425, April, 1996

Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences

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Semina, I.I., Baichurina, A.Z. & Garaev, R.S. Antineurotic effect of the hydrazide of O-β-chlorethyl-para-N-dimethylaminophenyl-phosphinylacetic acid (amphasid). Bull Exp Biol Med 121, 385–387 (1996). https://doi.org/10.1007/BF02446735

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  • DOI: https://doi.org/10.1007/BF02446735

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