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Effect of sodium hydroxybutyrate in pain syndromes

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that sodium hydroxybutyrate exerts a preventive and therapeutic effect on models of neuropathic pain syndrome and adjuvant arthritis. The effects of sodium hydroxybutyrate droxybutyrate are correlated with its ability to reduce hyperactivity of the neurons that are generators of pathologically enhanced excitation and to inhibit the pathological algetic system.

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References

  1. N. A. Kruglov and R. I. Kvasnoi, in:Sodium Hydroxybutyrate: Neuropharmacology and Clinical Studies [in Russian], Moscow (1968), pp. 5–18.

  2. G. N. Kryzhanovskii,Determinant Structures in Nervous System Pathology [in Russian], Moscow (1980).

  3. V. K. Reshetnyak and M. L. Kukushkin,Byull. Eksp. Biol. Med.,102, No. 11, 517–519 (1986).

    Google Scholar 

  4. A. S. Saratikov, L. L. Fisanova, T. A. Zamoshchina,et al., —Ibid.,101, No. 3, 312–315.

    Article  CAS  Google Scholar 

  5. E. B. Khaisman, L. A. Malikova, V. A. Arefolov, —Ibid.,100, No. 9, 317–319 (1985).

    CAS  Google Scholar 

  6. V. V. Churyukanov,in: Sodium Hydroxybutyrate: Neuropharmacology and Clinical Studies [in Russian], Moscow (1968), pp. 19–25.

  7. S. Armez and B. A. Meyerson,Pain,33, 11–23 (1988).

    Article  Google Scholar 

  8. M. J. Calado, J. Del Rio, and E. Peralta, —Ibid.,56, 3–8 (1994).

    Article  Google Scholar 

  9. G. Guilbaud, A. Levante, and I. Benoist, —Ibid., Suppl. 5, 277 (1990).

    Article  Google Scholar 

  10. V. Hechler, S. Gobaille, J. J. Bourguiguon,et al., J. Neurochem.,56, 938–942 (1991).

    PubMed  CAS  Google Scholar 

  11. M. Mamelok,Neurosci. Biobehav. Rev.,13, No. 4, 187–198 (1989).

    Article  Google Scholar 

  12. J. Neil-Fugazza, F. Codefroy, V. Manceau,et al., Brain Res.,374, 190–194 (1986).

    Article  Google Scholar 

  13. C. Schmidt, S. Gobaile, V. Hechler,et al., Eur. J. Pharmacol.,203, 393–397 (1991).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    E. I. Danilova, V. N. Grafova, R. U. Ostrovskaya & V. K. Reshetnyak

  2. Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    E. I. Danilova, V. N. Grafova, R. U. Ostrovskaya & V. K. Reshetnyak

Authors
  1. E. I. Danilova
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  2. V. N. Grafova
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  3. R. U. Ostrovskaya
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  4. V. K. Reshetnyak
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 395–398, April, 1996

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Danilova, E.I., Grafova, V.N., Ostrovskaya, R.U. et al. Effect of sodium hydroxybutyrate in pain syndromes. Bull Exp Biol Med 121, 359–362 (1996). https://doi.org/10.1007/BF02446727

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  • DOI: https://doi.org/10.1007/BF02446727

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