Abstract
Experiments on 5- and 10-month-old rats demonstrate a protective effect of active preimmunization with serotonin-protein conjugate on the development and course of the parkinsonismlike syndrome induced by intranigral injection of 1-methyl-4-phenylpyridinium+. The protective effect of antiserotonin antibodies was more pronounced in younger animals. The severity of manifestations of the syndrome may depend on the level of antidopamine autoantibodies.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 392–395, April, 1996
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Kryzhanovskii, G.N., Trekova, N.A., Basharova, L.A. et al. Effect of active immunization with serotonin-protein conjugate on the development of experimental Parkinson's syndrome. Bull Exp Biol Med 121, 356–358 (1996). https://doi.org/10.1007/BF02446726
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DOI: https://doi.org/10.1007/BF02446726