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Humoral factor(s) circulating in the blood of spontaneously hypertensive rats increases vascular tone and reduces constrictive responses of isolated rat caudal artery to stimulation of sympathetic fibers of the vascular wall

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that the perfusion pressure in isolated rat caudal artery rises and constrictive responses to electrical stimulation decrease when the blood of normotensive Wistar-Kyoto rats perfusing the vessel was replaced by the blood of spontaneously hypertensive rats. The norepinephrine release from the sympathetic terminals is reduced.

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References

  1. N. A. Medvedeva, S. Yu. Mashina, and O. S. Medvedev,Fiziol. Zh. SSSR.,74, No. 9, 1342–1344 (1988).

    Google Scholar 

  2. J. F. Gerkens,J. Pharmacol. Methods, No. 19, 135–147 (1988).

    Article  PubMed  CAS  Google Scholar 

  3. E. E. Muirhead,Hypertension, No. 2, 444–464 (1980).

    PubMed  CAS  Google Scholar 

  4. W. Zidek, U. Heckman, H. Losse, and H. Vetter,Clin. Exp. Hypertens. [A] 8, No. 3, 347–354 (1986).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov State University, Moscow

    N. A. Medvedeva, M. A. Zharkova & A. A. Chuiko

  2. Department of Pharmacology, Faculty of Fundamental Medicine, M. V. Lomonosov State University, Moscow

    O. S. Medvedev

Authors
  1. N. A. Medvedeva
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  2. M. A. Zharkova
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  3. A. A. Chuiko
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  4. O. S. Medvedev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 380–382, April, 1996

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Medvedeva, N.A., Zharkova, M.A., Chuiko, A.A. et al. Humoral factor(s) circulating in the blood of spontaneously hypertensive rats increases vascular tone and reduces constrictive responses of isolated rat caudal artery to stimulation of sympathetic fibers of the vascular wall. Bull Exp Biol Med 121, 345–347 (1996). https://doi.org/10.1007/BF02446723

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  • DOI: https://doi.org/10.1007/BF02446723

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