Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 4, pp 339–340 | Cite as

Dopaminergic mechanisms in the immunostimulating effect of μ-opioid receptors

  • M. A. Cheido
  • G. V. Idova
Physiology

Abstract

Immunogenesis was appreciably stimulated in CBA mice injected the μ-opioid receptor agonist DAGO. This stimulation was prevented by transecting the pituitary peduncle. Immunoactivation induced by opioid peptide was due to interaction with the dopaminergic system, because the effect is canceled by preliminary haloperidol blocking of D2-postsynaptic receptors.

Key Words

μ-opioid receptors immunostimulation dopaminergic system 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • M. A. Cheido
    • 1
  • G. V. Idova
    • 1
  1. 1.Institute of PhysiologySiberian Division of the Russian Academy of Medical SciencesNovosibirsk

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