Biodegradable copolymers based on p-dioxanone for medical application

  • C. X. Song
  • X. M. Cui
  • A. Schindler


Biodegradable polymer Drug delivery p-dioxanone Surgical suture 


  1. BOURNE, R. B., BITARH, H., ANDREAE, P. R., MARTIN, L. M., and FINLAY, J. B. (1988) In-viva comparison of four absorbable sutures: Vicryl, Dexon plus, Maxon and PDS. Canad. J. Surg., 31, 43–45.Google Scholar
  2. FENG, X. D., SONG, C. X. and CHEN, W. Y. (1983) Synthesis and evaluation of biodegradable block copolymers of a-caprolactone and d,l-lactide. Polym. ScL, Suppl., Polym. Lett., 21,593–600.CrossRefGoogle Scholar
  3. KITOH, S. S. and ISHII, Y. (1966) J. Org. Chem., 31, 3948–3951.CrossRefGoogle Scholar
  4. KULKARNI, R. K., PANI, K. C., NEUMAN, C. and LEONARD, F. (1971) Biodegradable poly(lactide acid). J. Biomed. Mater. Res., 5, 169–181.PubMedCrossRefGoogle Scholar
  5. LANGER, R. and CHASIN, M. (Eds.) (1990) Biodegradable polymers as drug delivery system. Marcel Deckker, New York, NY, USA, 121–161.Google Scholar
  6. PITT, C. G., GRATZL, M. M., KIMMEL, G. L., SURLES, J. and SCHINDLER, A. (1981) Aliphatic polyesters. II. The degradation of poly(d,l-lactide), poly(e-caprolactone) and their copolymers in vivo. Biomaterials 2, 215–220.PubMedCrossRefGoogle Scholar
  7. RAY, J. A., REGULA, D., WILLIAMS, J. A. and MELVEGER, A. (1981) Polydioxanone (PDS), a novel monofilament synthetic absorbable suture. Sur 9. Gynecol. & Obstet., 153, 497–507.Google Scholar
  8. SCHINDLER, A., JEFFCOAT, R., KIMMEL, G. L. PITT, C. G., WALL, M. E. and ZWEIDINGER, R. (1977) In Contemporary topics in polymer science, Vol. 2, PEARCE, E. M. and SCHAEFGEN, J. R. (Eds). Plenum, 251–289.Google Scholar
  9. SONG, C. X. and FENG, X. D. (1986) Synthesis and evaluation of biodegradable ABA tribilock copolymer of -caprolactone and d,l-lactide as drug release delivery. Polymer Comm. (Chinese), 2, 108–114.Google Scholar

Copyright information

© IFMBE 1993

Authors and Affiliations

  • C. X. Song
    • 1
  • X. M. Cui
    • 1
  • A. Schindler
    • 2
  1. 1.Institute of Biomedical EngineeringChinese Academy of Medical ScienceTianjinChina
  2. 2.Research Triangle InstituteResearch Triangle ParkUSA

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