Time course of the cytotoxicity of blood mononuclears in patients with bladder cancer during endolymphatic immunotherapy with lymphokine-activated killers and recombinant interleukin-2
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A specific stimulation of mononuclear cellsin vivo was observed after 3 or 4 endolymphatic injections of autologous lymphokine-activated killers and recombinant interleukin-2 in male patients with disseminated bladder cancer. This activation presented as an increase of the cytotoxicity of mononuclears towards target cells of bladder carcinoma. A statistically reliable increase of natural killer activity was observed, and in one patient a reliable increase of the cytolytic activity of mononuclear cells against Mel-1 target cells. After 1 or 2 injections the activity of natural killers increased to 80–90% for an initial level of 23–50%.
Key Wordsantitumor immunity bladder cancer immunotherapy interleukin-2 lymphokine-activated killers
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