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Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 2, pp 174–177 | Cite as

Time course of the cytotoxicity of blood mononuclears in patients with bladder cancer during endolymphatic immunotherapy with lymphokine-activated killers and recombinant interleukin-2

  • N. V. Malakhova
  • K. M. Figurin
  • N. S. Fedorova
  • M. V. Kiselevskii
  • S. N. Bykovskaya
Experimental Methods for Clinical Practice
  • 18 Downloads

Abstract

A specific stimulation of mononuclear cellsin vivo was observed after 3 or 4 endolymphatic injections of autologous lymphokine-activated killers and recombinant interleukin-2 in male patients with disseminated bladder cancer. This activation presented as an increase of the cytotoxicity of mononuclears towards target cells of bladder carcinoma. A statistically reliable increase of natural killer activity was observed, and in one patient a reliable increase of the cytolytic activity of mononuclear cells against Mel-1 target cells. After 1 or 2 injections the activity of natural killers increased to 80–90% for an initial level of 23–50%.

Key Words

antitumor immunity bladder cancer immunotherapy interleukin-2 lymphokine-activated killers 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • N. V. Malakhova
    • 1
  • K. M. Figurin
    • 1
  • N. S. Fedorova
    • 1
  • M. V. Kiselevskii
    • 1
  • S. N. Bykovskaya
    • 1
  1. 1.Laboratory of Cell-Mediated Immunity, Department of Urology, N. N. Blokhin Cancer Research CenterRussian Academy of Medical SciencesMoscow

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