Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 2, pp 142–144 | Cite as

Significance of various adrenoreceptors for brain resistance to total ischemia

  • V. I. Kulinskii
  • T. N. Medvedeva
Biophysics and Biochemistry
  • 19 Downloads

Abstract

In contrast to the β-agonist isoprenaline and the α1-agonist phenylephrine, the α2-agonists clonidine, guanobenz, and methyldopa are highly effective against total brain ischemia. Epinephrine in itself is inactive but displays protective activity against the background of the β-antagonist propranolol. The α2-antagonist rauwolscine, but not α1-antagonists, abolish the protective effect of clonidine.

Key Words

adrenoreceptors brain protectors brain ischemia 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • V. I. Kulinskii
    • 1
  • T. N. Medvedeva
    • 1
  1. 1.Department of BiochemistryIrkutsk Medical InstituteIrkutskUSSR

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