Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 2, pp 142–144 | Cite as

Significance of various adrenoreceptors for brain resistance to total ischemia

  • V. I. Kulinskii
  • T. N. Medvedeva
Biophysics and Biochemistry


In contrast to the β-agonist isoprenaline and the α1-agonist phenylephrine, the α2-agonists clonidine, guanobenz, and methyldopa are highly effective against total brain ischemia. Epinephrine in itself is inactive but displays protective activity against the background of the β-antagonist propranolol. The α2-antagonist rauwolscine, but not α1-antagonists, abolish the protective effect of clonidine.

Key Words

adrenoreceptors brain protectors brain ischemia 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. I. Kulinskii,in: Radiation Biology. Radioecology [in Russian],33, № 6, 831–847 (1993).Google Scholar
  2. 2.
    V. I. Kulinskii,Vopr. Med. Khimii,40, № 6, 13–17 (1994).PubMedGoogle Scholar
  3. 3.
    V. I. Kulinskii, I. A., Ol'khovskii, and A. N. Kovalevskii,Byull. Eksp. Biol. Med.,101, № 6, 669–671 (1986).Google Scholar
  4. 4.
    V. I. Kulinskii, L. A. Usov, G. Z. Sufianova,et al., Eksp. Klin. Farmakol.,56, № 6, 13–16 (1993).PubMedGoogle Scholar
  5. 5.
    P. V. Sergeev and N. L. Shimanovskii,Receptors for Physiologically Active Compounds [in Russian], Moscow (1987).Google Scholar
  6. 6.
    W. E. Hoffman, M. A. Cheng, C. Thomas,et al., Anesth. Analg.,73, № 4, 460–464 (1991).PubMedGoogle Scholar
  7. 7.
    W. E. Hoffman, E. Kochs, C. Werner,et al., Anesthesiology,75, № 2, 328–332 (1991).PubMedCrossRefGoogle Scholar
  8. 8.
    C. Maier, G. K. Streinberg, Guo Hua Sun,et al. —Ibid.,79, № 2, 306–312 (1993).PubMedGoogle Scholar
  9. 9.
    K. A. Rudolphi, P. Schubert, F. E. Parkinson, and B. B. Fredholm,Trends Pharmacol. Sci.,13, № 12, 439–445 (1992).PubMedCrossRefGoogle Scholar
  10. 10.
    R. R. Ruffolo, A. J. Nichols, J. M. Stadel, and J. P. Hieble,Pharmacol. Rev.,43, 475–505 (1991).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • V. I. Kulinskii
    • 1
  • T. N. Medvedeva
    • 1
  1. 1.Department of BiochemistryIrkutsk Medical InstituteIrkutskUSSR

Personalised recommendations