Abstract
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver, and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of 11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 2, pp. 138–143, February, 1996
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Khachatur'yan, M.L., Gukasov, V.M., Komarov, P.G. et al. Comparison of lipid peroxidation parameters in the heart, liver, and brain of rats with different degrees of resistance to hypoxia. Bull Exp Biol Med 121, 126–131 (1996). https://doi.org/10.1007/BF02446615
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DOI: https://doi.org/10.1007/BF02446615