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Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 3, pp 915–917 | Cite as

Main lymphoid subpopulations and their mitogenic response after lethal irradiation and transplantation of syngeneic bone marrow from young and old donors

  • G. M. Butenko
  • Yu. G. Kudinov
  • T. V. Maksyuk
  • I. N. Pishel'
  • D. A. Bazyka
  • N. V. Belyaeva
  • M. V. Azarskova
Microbiology and Immunology

Abstract

The recovery of T-lymphocyte subpopulations depends on the age of the stem cell donor. After transplantation of bone marrow cells from old donors, the CD4+ and CD8+ cell counts decrease, while the number of cells with the memory cell phenotype (CD4+CD44high) in the CD4+-lymphocyte population increases. Lymphocyte proliferation in irradiated mice does not depend on the age of the stem cell donor. Our findings indicate that bone marrow stem cells change with age and transfer information regarding the donor's age.

Key Words

aging bone marrow irradiation T lymphocytes 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • G. M. Butenko
    • 1
  • Yu. G. Kudinov
    • 1
  • T. V. Maksyuk
    • 1
  • I. N. Pishel'
    • 1
  • D. A. Bazyka
    • 2
  • N. V. Belyaeva
    • 2
  • M. V. Azarskova
    • 2
  1. 1.Department of Immunology Institute of GerontologyUkrainian Academy of Medical SciencesKiev
  2. 2.Department of Clinical Immunology, Center of Radiation MedicineUkrainian Academy of Medical SciencesKiev

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