Letters in Peptide Science

, Volume 8, Issue 3–5, pp 289–294 | Cite as

Peptide delivery systems

  • M. Ali
  • N. Manolios


Efficient delivery of peptide drugs to the desired site is very important. There are a number of barriers that may limit using peptides as potential drugs, some of these obstacles include poor biomembrane permeability, enzymatic degradation and low pH. To improve peptide drug efficiency a selective drug delivery system is required. Here we review some of the delivery systems available for peptides and we will also briefly discuss peptides that have been used as delivery systems.

Key words

delivery system lipopeptide liposaccharide liposome peptide polyethylene glycol 



core peptide


cytolytic T cells














human serum transferin


poly ethylene glycol


poly(ethylene glycol)-poly(β-benzyl-L-aspartate) block copolymer


PEGylated poly(lactic-co-glycolic acid)


fluorescein isothiocyanate


leucine aminopeptidase


luteinizing hormone releasing hormone; tris, 2-amino-2-hydroxy-methyl-1,3-propanediol


tris-glycine-tripalmitate; tripam-c, S-[2,3-bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-cysteine


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  1. 1.
    Bechinger, B., Biochim. Biophys. Acta, 1462 (1999) 157.PubMedCrossRefGoogle Scholar
  2. 2.
    Wade, J.D., Smith, K.J., Claasz, A.A., Otvos Jr., L., Temelcos, C., Kubota, Y., Hutson, J.M., Tregear, G.W. and Bathgate, R.A., J. Pept. Sci., 7 (2001) 495.PubMedCrossRefGoogle Scholar
  3. 3.
    Sinha, V.R. and Kumria, R., Internat. J. Pharm., 224 (2001) 19.CrossRefGoogle Scholar
  4. 4.
    Liu, Z., Wu, X.Y., Ballinger, J.R. and Bendayan, R., J. Pharm. Sci., 89 (2000) 807.PubMedCrossRefGoogle Scholar
  5. 5.
    Bernkop-Schnurch, A., Internat. J. Pharm., 194 (2000) 1.CrossRefGoogle Scholar
  6. 6.
    Drouillat, B., Hillery, A.M., Dekany, G., Falconer, R., Wright, K. and Toth, I., J. Pharm. Sci., 87 (1998) 25.PubMedCrossRefGoogle Scholar
  7. 7.
    Lowell, G.H., Ballou, W.R., Smith, L.F., Wirtz, R.A., Zollenger, W.D. and Hockmeyer, W.T., Science, 240 (1988) 800.PubMedGoogle Scholar
  8. 8.
    Weismuller, K., Bessler, W.G. and Jung, G., Int. J. Pept. Prot. Res., 40 (1992) 255.CrossRefGoogle Scholar
  9. 9.
    Verheul, A.F.M., Udhayakumar, V., Jue, D., Wohlhueter, R.B. and Lai, A.A., J. Immunol. Meth., 182 (1995) 219.CrossRefGoogle Scholar
  10. 10.
    Hashizume, M., Douen, T., Murakami, M., Yamamoto, A., Takada, K. and Muranishi, S., J. Pharm. Pharmacol., 44 (1991) 555.Google Scholar
  11. 11.
    Whittaker, R.G., Hayes, P.J. and Bender, V.J., Pept. Resear., 6 (1993) 125.Google Scholar
  12. 12.
    Manolios, N., Collier, S., Taylor, J., Pollard, J., Harrison, L. and Bender, V., Nature Medicine, 3 (1997) 84.PubMedCrossRefGoogle Scholar
  13. 13.
    Manolios, N., Ali, M. and Kurosaka, N., 4th Australian Peptide Conference, Lindeman Island, Queensland, Australia, October 7–12, 2001.Google Scholar
  14. 14.
    Thiam, K., Loing, E., Verwaerde, C., Auriault, C. and Gras-Masse, H., J. Med. Chem., 42 (1999) 3732.PubMedCrossRefGoogle Scholar
  15. 15.
    Bonnet, D., Thiam, K., Loing, E., Melnyk, O. and Gras-Masse, H., J. Med. Chem., 44 (2001) 468.PubMedCrossRefGoogle Scholar
  16. 16.
    Ryman, B.E. and Tyrrell, D.A., Essays Biochem., 16 (1980) 49.PubMedGoogle Scholar
  17. 17.
    Bundgaard, H., Hansen, A.B., Kofod, H., Optimisation of Drug Delivery, Munksgaard, Copenhagen, 1982, pp. 351–353.Google Scholar
  18. 18.
    Gyongyossy-Issa, M.I.C., Muller, W. and Devine, D.V., Arch. Biochem. Biophys., 353 (1998) 101.PubMedCrossRefGoogle Scholar
  19. 19.
    Babu, J. S., Nair, S., Kanda, P. and Rouse, B.T., Vaccine, 13 (1995) 1669.PubMedCrossRefGoogle Scholar
  20. 20.
    Pettit, D.K. and Gombotz, W.R., Trends in Biotechn., 16 (1998) 343.CrossRefGoogle Scholar
  21. 21.
    Li, Y., Pei, Y., Zhang, X., Gu, Z., Zhou, Z., Yuan, W., Zhou, J., Zhu, J. and Gao, X., J. Contr. Release, 71 (2001) 203.CrossRefGoogle Scholar
  22. 22.
    Huang, S., Pooyan, S., Wang, J., Choudhury, I., Leibowitz, M.J. and Stein, S., Bioconj. Chem., 9 (1998) 612.CrossRefGoogle Scholar
  23. 23.
    Yamazaki, Y., Tsuruga, M., Gentsch, B., Oka, S., Kleinman, H.K. and Mokotoff, M., Anticancer Research, 20 (2000) 1381.PubMedGoogle Scholar
  24. 24.
    Kasugai, S, Fujisawa, R., Waki, Y., Miyamoto, K. and Ohya, K., J. Bone Mineral Research, 15 (2000) 936.CrossRefGoogle Scholar
  25. 25.
    Ali, S.A., Joao, H.C., Hammerschmid, F., Eder, J. and Steinkasserer, A., FEBS Lett., 459 (1999) 230.PubMedCrossRefGoogle Scholar
  26. 26.
    Smith, L.C., Duguid, J., Wadhwa, M.S., Logan, M.J., Tung, C., Edwards, V. and Sparrow, J.T., Adv. Drug Delivery Rev., 30 (1998) 115.CrossRefGoogle Scholar
  27. 27.
    Patel, S., Zhang, X., Collins, L. and Fabre, J.W., J. Gene Medicine, 3 (2001) 271.CrossRefGoogle Scholar
  28. 28.
    Wadih, A., Pasqualini, R. and Ruoslahti, E., Science, 279 (1998) 377.CrossRefGoogle Scholar
  29. 29.
    Ye, Q., Asherman, J., Stevenson, M., Brownson, E. and Katre, N.V., J. Contr. Release, 64 (2000) 155.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  1. 1.Department of RheumatologyWestmead HospitalSydneyAustralia

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