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Letters in Peptide Science

, Volume 8, Issue 3–5, pp 289–294 | Cite as

Peptide delivery systems

  • M. Ali
  • N. Manolios
Article

Summary

Efficient delivery of peptide drugs to the desired site is very important. There are a number of barriers that may limit using peptides as potential drugs, some of these obstacles include poor biomembrane permeability, enzymatic degradation and low pH. To improve peptide drug efficiency a selective drug delivery system is required. Here we review some of the delivery systems available for peptides and we will also briefly discuss peptides that have been used as delivery systems.

Key words

delivery system lipopeptide liposaccharide liposome peptide polyethylene glycol 

Abbreviations

CP

core peptide

CTL

cytolytic T cells

DMPC

1,2-dimyristoyl-sn-glycero-3-phosphocholine

DOX

doxorubicin

DSPE

distearoylphosphatidyl-ethanolamine

DSPE

distearoylphosphatidylethanolamine

PDP-DOPE

1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine-N-[3-(2-pyridyldithio)propionate]

HA

hydroxyapatite

HST

human serum transferin

PEG

poly ethylene glycol

PEG-PBLA

poly(ethylene glycol)-poly(β-benzyl-L-aspartate) block copolymer

PEG-PLGA

PEGylated poly(lactic-co-glycolic acid)

FITC

fluorescein isothiocyanate

LAPN

leucine aminopeptidase

LHRH

luteinizing hormone releasing hormone; tris, 2-amino-2-hydroxy-methyl-1,3-propanediol

LP3

tris-glycine-tripalmitate; tripam-c, S-[2,3-bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-cysteine

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  1. 1.Department of RheumatologyWestmead HospitalSydneyAustralia

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