Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4
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The relationship between interleukin-4-induced synthesis of immunoglobulin E (IgE) by peripheral blood mononuclear cells of healthy donors and the expression of T- and B-cell surface differentiating markers is studied. It is demonstrated that the high level of IgE response on day 10 of culturing correlates with a higher level of expression of the T-cell activation markers HLA-DR and CD25 and a low level of expression of the low-affinity IgE receptor CD23 on the surface of B cells. Activation of T cells is interleukin-4-independent, since it occurs to an equal degree when these cells are cultured without interleukin-4.
Key Wordsinterleukin-4 surface antigens immunoglobulin E
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