Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 4, pp 1121–1125 | Cite as

Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4

  • R. G. Vasilov
  • L. K. Chelidze
  • Yu. S. Lebedin
  • S. V. Chukanova
  • E. N. Tsytsikov
  • V. I. Pivnyuk
New Biomedical Technologies


The relationship between interleukin-4-induced synthesis of immunoglobulin E (IgE) by peripheral blood mononuclear cells of healthy donors and the expression of T- and B-cell surface differentiating markers is studied. It is demonstrated that the high level of IgE response on day 10 of culturing correlates with a higher level of expression of the T-cell activation markers HLA-DR and CD25 and a low level of expression of the low-affinity IgE receptor CD23 on the surface of B cells. Activation of T cells is interleukin-4-independent, since it occurs to an equal degree when these cells are cultured without interleukin-4.

Key Words

interleukin-4 surface antigens immunoglobulin E 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • R. G. Vasilov
    • 1
  • L. K. Chelidze
    • 1
  • Yu. S. Lebedin
    • 2
  • S. V. Chukanova
    • 3
  • E. N. Tsytsikov
    • 1
  • V. I. Pivnyuk
    • 1
  1. 1.Laboratory of Molecular ImmunologyInstitute of BiotechnologyMoscow
  2. 2.Institute of PulmonologyRussian Ministry of HealthMoscow
  3. 3.Institute of ImmunologyRussian Ministry of HealthMoscow

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