Lipid peroxidation in the brain of rats differing in resistance to emotional stress
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It is found for each of the rat brain regions studied (cerebral cortex, subjacent white substance, and brainstem) that both the initial levels of 2-thiobarbituric acid-reactive products and the rates of their increment are highest in rats resistant to emotional stress and lowest in stress-prone rats, and that the rates at which lipid peroxidation products accumulate are highest in the brainstem and lowest in the white substance. A correlation is presumed to exist between individual resistance to cerebral ischemia and the rate of lipid peroxidation in particular brain regions of healthy rats.
Key wordslipid peroxidation rat brain open-field behavior
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