Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 4, pp 1085–1087 | Cite as

Lipid peroxidation in the brain of rats differing in resistance to emotional stress

  • M. L. Kuklei
  • S. L. Stvolinskii
  • A. A. Boldyrev
  • I. V. Gannushkina
Pathological Physiology and General Pathology


It is found for each of the rat brain regions studied (cerebral cortex, subjacent white substance, and brainstem) that both the initial levels of 2-thiobarbituric acid-reactive products and the rates of their increment are highest in rats resistant to emotional stress and lowest in stress-prone rats, and that the rates at which lipid peroxidation products accumulate are highest in the brainstem and lowest in the white substance. A correlation is presumed to exist between individual resistance to cerebral ischemia and the rate of lipid peroxidation in particular brain regions of healthy rats.

Key words

lipid peroxidation rat brain open-field behavior 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    I. V. Gannushkina, A. L. Antelava and M. V. Baranchikova,Bull. Eksp. Biol. Med.,118, № 10, 360–363 (1994).Google Scholar
  2. 2.
    P. P. Golikov, B. V. Davydov, and S. B. Matveev,Vopr. Med. Khim.,33, № 1, 47 (1987).PubMedGoogle Scholar
  3. 3.
    E. V. Gubler and A. A. Genkin,Use of Nonparametric Statistical Tests in Biomedical Research [in Russian], Leningrad (1973).Google Scholar
  4. 4.
    A. L. Markel' and R. A. Khusainov,Zh. Vyssh. Nervn. Deyat., № 6, 1314 (1976).Google Scholar
  5. 5.
    Yu. G. Skotselyas, E. A. Yumatov, and E. M. Krokhina, in:Models and Methods for the Study of Various Types of Experimental Emotional Stress. Proc. All-Union Symposium [in Russian], Volgograd (1977), p. 175.Google Scholar
  6. 6.
    K. V. Sudakov,Pat. Fiziol., №, 1, 3 (1989).Google Scholar
  7. 7.
    K. V. Sudakov, T. I. Belova, and E. A. Yumatov, in:Arterial. Hypertension, Proc. Soviet-American Symposium [in Russian], Moscow (1980), p. 170.Google Scholar
  8. 8.
    K. V. Sudakov, E. A. Yumatov, and L. S. Ul'yaninskii,Fiziol. Zh. SSSR,74, № 11, 1535 (1988).Google Scholar
  9. 9.
    Hasan Mahdi and S. Fatehyab Ahi,Toxicol. Appl. Pharmacol., 57, № 1, 8 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    H. I. Kohn and et al.,J. Pharmacol.,82 № 2, 292 (1944).Google Scholar
  11. 11.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall,J. Biol. Chem.,193, № 1, 265 (1951).PubMedGoogle Scholar
  12. 12.
    Y. Nodaet al., J. Neurochem.,40, №5, 1329 (1983).PubMedGoogle Scholar
  13. 13.
    G. T. Vatassery, J. F. Berry, R. Younorai, and L. Bergad,Lipids,11, № 4, 317 (1976).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • M. L. Kuklei
    • 1
  • S. L. Stvolinskii
    • 1
  • A. A. Boldyrev
    • 1
  • I. V. Gannushkina
    • 1
  1. 1.Laboratory for Experimental Pathology of the Nervous System and Laboratory of Neurochemistry, Research Institute of NeurologyRussian Academy of Medical SciencesMoscow

Personalised recommendations