Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 1, pp 715–717 | Cite as

Recovery of colony-forming capacity of murine stem hemopoietic and blood cells under the effect of 1-β-D-arabinofuranosyl cytosine

  • V. A. Kozlov
  • V. M. Novikova
  • P. N. Filimonov
Microbiology and Immunology
  • 18 Downloads

Abstract

The cytostatic 1-β-D-arabinofuranosyl cytosine (cytarabine) in a dose of 200 mg/kg decreases blood count of nuclear cells in mice, to 60% and inhibits colony formation in the spleen for 8 days. The Resist repair system developed by us normalizes the total count within 3 days after cytarabine injection and repairs colony-forming activity of stem hemopoietic cells within 5 days, if Resist is injected after the, cytostatic, and within 8 days, if it is injected before cytarabine. Thus, Resist restores, immunity and hemopoiesis systems in cancer patients treated by radio- and chemotherapy.

Key Words

1-β-D-arabinofuranosyl cytosine stem hemopoietic cell blood cells Resist 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • V. A. Kozlov
    • 1
  • V. M. Novikova
    • 1
  • P. N. Filimonov
    • 1
  1. 1.Institute of Clinical ImmunologySiberian Division of Russian Academy of Medical SciencesNovosibirsk

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