Recovery of colony-forming capacity of murine stem hemopoietic and blood cells under the effect of 1-β-D-arabinofuranosyl cytosine
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The cytostatic 1-β-D-arabinofuranosyl cytosine (cytarabine) in a dose of 200 mg/kg decreases blood count of nuclear cells in mice, to 60% and inhibits colony formation in the spleen for 8 days. The Resist repair system developed by us normalizes the total count within 3 days after cytarabine injection and repairs colony-forming activity of stem hemopoietic cells within 5 days, if Resist is injected after the, cytostatic, and within 8 days, if it is injected before cytarabine. Thus, Resist restores, immunity and hemopoiesis systems in cancer patients treated by radio- and chemotherapy.
Key Words1-β-D-arabinofuranosyl cytosine stem hemopoietic cell blood cells Resist
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- 1.M. L. Gershanovich, S. A. Ketlinskii, L. V. Filatova,et al., Vopr. Onkol., No. 6, 13–18 (1966).Google Scholar
- 2.L. A. Makhonova, A. V. Kiselev, G. A. Gordina, and Z. G. Kadazhdze,Ibid.,, No. 2, 80–81 (1995).Google Scholar
- 3.V. M. Novikova and V. A. Kozlov,Immunologiya, No. 5, 40–45 (1980).Google Scholar
- 4.V. M. Novikova, N. V. Mikhalin, I. S. Alfer'ev, and V. A., Kozlov,Radiats. Biol. Radioekol.,36, No. 1, 30–35 (1996).Google Scholar
- 5.R. V. Petrov and V. M. Man'ko,Immunosuppressants [in Russian], Moscow (1971).Google Scholar
- 6.N. I. Perevodchikova, ed.,Antitumor Chemotherapy [in Russian], Moscow (1986).Google Scholar
- 9.P. Morales-Ramires, R. Rodriguez-Reyes, and T. Vallarino-Kelly,Ibid.,,232, No. 1, 77–88 (1990), 4Google Scholar