Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 1, pp 653–657 | Cite as

Changes in the ultrastructure of axospike contacts in human brain during normal aging and in vascular disorders

  • L. E. Frumkina
  • N. I. Yakovleva
  • N. N. Bogolepov
Physiology
  • 23 Downloads

Abstract

Light spikes, the majority of which are electron-transparent, are the main structural unit of the axospike contacts in normal brain of aged people (73 and 83 years). Dark spikes and spikes with moderate osmiophilia predominate in the brain of people with vascular disorders at the age of 70–73 years. A “synaptic block”, which was morphologically represented by presynaptic terminals with densely packed synaptic vesicles, is revealed in the brain of aged people with vascular disorders. The role of hypoxia in the reorganization of axospike synapes is discussed. It is hypothesized that changes in the structure of axospike contacts in normal aging and vascular disorders are associated with modifications in the ultrastructure of spikes.

Key words

axospike contact dendrite spike spike apparatus aging vascular disorders 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. L. Luk'yanova,Tsitologiya, No. 10, 1176–1179 (1989).Google Scholar
  2. 2.
    L. E. Frumkina, N. I. Yakovleva, T. V. Vorob'yova,et al., Arkh. Anat.,90, No. 10, 5–12 (1989).Google Scholar
  3. 3.
    R. K. S. Calverley and D. G. Jones,Brain Res. Brain Res. Res.,15, No. 3, 215–249 (1990).Google Scholar
  4. 4.
    D. W. Choi,J. Neurosci.,10, 2493–2501 (1990).PubMedGoogle Scholar
  5. 5.
    C. H. Homer,Prog. Neurobiol.,41, No. 3, 281–321 (1993).Google Scholar
  6. 6.
    T. Kirino,Prog. Brain. Res. 96, 261–270 (1993).PubMedCrossRefGoogle Scholar
  7. 7.
    Ch. Koch and A. Zador,J. Neurosci.,13, No. 2, 413–422 (1993).PubMedGoogle Scholar
  8. 8.
    M. Morales and E. Fifkova,J. Comp. Neurol.,279, No. 4, 666–674 (1989).PubMedCrossRefGoogle Scholar
  9. 9.
    M. Segal,Trends Neurosci.,18, 468–471 (1995).PubMedCrossRefGoogle Scholar
  10. 10.
    J. Spacek and K. M. Harris,J. Neurosci.,17, No. 1, 190–203 (1997).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • L. E. Frumkina
    • 1
  • N. I. Yakovleva
    • 1
  • N. N. Bogolepov
    • 1
  1. 1.Laboratory of Brain Ultrastructure, Institute of Brain ResearchRussian Academy of Medical SciencesMoscow

Personalised recommendations