Changes in the ultrastructure of axospike contacts in human brain during normal aging and in vascular disorders
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Light spikes, the majority of which are electron-transparent, are the main structural unit of the axospike contacts in normal brain of aged people (73 and 83 years). Dark spikes and spikes with moderate osmiophilia predominate in the brain of people with vascular disorders at the age of 70–73 years. A “synaptic block”, which was morphologically represented by presynaptic terminals with densely packed synaptic vesicles, is revealed in the brain of aged people with vascular disorders. The role of hypoxia in the reorganization of axospike synapes is discussed. It is hypothesized that changes in the structure of axospike contacts in normal aging and vascular disorders are associated with modifications in the ultrastructure of spikes.
Key wordsaxospike contact dendrite spike spike apparatus aging vascular disorders
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