Skip to main content
SpringerLink
Log in

Changes in the ultrastructure of axospike contacts in human brain during normal aging and in vascular disorders

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Light spikes, the majority of which are electron-transparent, are the main structural unit of the axospike contacts in normal brain of aged people (73 and 83 years). Dark spikes and spikes with moderate osmiophilia predominate in the brain of people with vascular disorders at the age of 70–73 years. A “synaptic block”, which was morphologically represented by presynaptic terminals with densely packed synaptic vesicles, is revealed in the brain of aged people with vascular disorders. The role of hypoxia in the reorganization of axospike synapes is discussed. It is hypothesized that changes in the structure of axospike contacts in normal aging and vascular disorders are associated with modifications in the ultrastructure of spikes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. L. Luk'yanova,Tsitologiya, No. 10, 1176–1179 (1989).

    Google Scholar 

  2. L. E. Frumkina, N. I. Yakovleva, T. V. Vorob'yova,et al., Arkh. Anat.,90, No. 10, 5–12 (1989).

    Google Scholar 

  3. R. K. S. Calverley and D. G. Jones,Brain Res. Brain Res. Res.,15, No. 3, 215–249 (1990).

    CAS  Google Scholar 

  4. D. W. Choi,J. Neurosci.,10, 2493–2501 (1990).

    PubMed  CAS  Google Scholar 

  5. C. H. Homer,Prog. Neurobiol.,41, No. 3, 281–321 (1993).

    Google Scholar 

  6. T. Kirino,Prog. Brain. Res. 96, 261–270 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. Ch. Koch and A. Zador,J. Neurosci.,13, No. 2, 413–422 (1993).

    PubMed  CAS  Google Scholar 

  8. M. Morales and E. Fifkova,J. Comp. Neurol.,279, No. 4, 666–674 (1989).

    Article  PubMed  CAS  Google Scholar 

  9. M. Segal,Trends Neurosci.,18, 468–471 (1995).

    Article  PubMed  CAS  Google Scholar 

  10. J. Spacek and K. M. Harris,J. Neurosci.,17, No. 1, 190–203 (1997).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Brain Ultrastructure, Institute of Brain Research, Russian Academy of Medical Sciences, Moscow

    L. E. Frumkina, N. I. Yakovleva & N. N. Bogolepov

Authors
  1. L. E. Frumkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. I. Yakovleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. N. Bogolepov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 7, pp. 15–19, July, 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Frumkina, L.E., Yakovleva, N.I. & Bogolepov, N.N. Changes in the ultrastructure of axospike contacts in human brain during normal aging and in vascular disorders. Bull Exp Biol Med 126, 653–657 (1998). https://doi.org/10.1007/BF02446050

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02446050

Key words

Search

Navigation