Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 1, pp 755–758 | Cite as

Correction of lipid metabolism with chenodeoxycholic acid and galenic preparations in experiment

  • Yu. A. Bogdarin
  • O. V. Vinnitskaya
Experimental Methods for Clinical Practice
  • 20 Downloads

Abstract

In a rabbit model of cholestasis (40% ligation of the common bile duct), the size and number of cholesterol calculi in the gallbladder drop markedly after therapy with chenodeoxycholic acid (1.5 mg/kg once daily for 2–3 months) or with the new galenic preparation ekvalen (daily administration in a dose of 1.5 ml/kg in a 16–18% aqueous ethanol solution for 7 days at 3–4-day intervals during a 1–3-month period). Normalization of lipid metabolism in the enterohepatic system is documented.

Key Words

cholestasis lipid metabolism chenodeoxycholic acid galenic preparations 

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References

  1. 1.
    Yu. A. Bogdarin,Peculiarities of Lipid Composition in the Enterohepatic System and Its Correction in Cholelithiasis, D. Sci. Dissertation [in Russian], Gorky (1990).Google Scholar
  2. 2.
    Yu. A. Bogdarin, A. V. Galkin, I. B. Denisova, and A. S. Vizgalova,Method of Preparation of Individual Bile Acids, Russian Federation Patent No. 166568 November 22, 1991.Google Scholar
  3. 3.
    Yu. A. Bogdarin,Drug for the Prevention and Treatment of Cholecystitis and Cholelithiasis, Russian Federation Patent No. 5068531, October 17, 1994.Google Scholar
  4. 4.
    Yu. P. Ipatov,Clinical Significance of X-Ray and Ultrasound Diagnostics of Gastroduodenal and Pancreatobiliar Disorders in Children, MD. Dissertation [in Russian], Gorky (1989).Google Scholar
  5. 5.
    D. I. Krivitskii, N. N. Gvozdyak, H. G. Polyakov, and A. A. Nikitenko,Vestn. Khir.,134, No. 7, 46–49 (1985).PubMedGoogle Scholar
  6. 6.
    A. S. Loginov, S. M. Chebanov, Yu. Kh. Marakhovskii, and I. I. Goncharik,Byull. Eksp. Biol. Med.,108, No. 8, 251–254 (1989).Google Scholar
  7. 7.
    Kh. Kh. Mansurov, in:Problems of Gastroenterology [in Russian], V. Kh. Vasilenko (Ed.), Vol. 7, Dushanbe (1987), pp. 9–20.Google Scholar
  8. 8.
    S. Ya. Sokolov and I. P. Zamotaev,A Reference Book of Medicinal Plants [in Russian], Moscow (1989).Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Yu. A. Bogdarin
    • 1
  • O. V. Vinnitskaya
    • 1
  1. 1.Institute of Children GastroenterologyMinistry of Health of RussiaNizhni Novgorod

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