Correction of lipid metabolism with chenodeoxycholic acid and galenic preparations in experiment
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In a rabbit model of cholestasis (40% ligation of the common bile duct), the size and number of cholesterol calculi in the gallbladder drop markedly after therapy with chenodeoxycholic acid (1.5 mg/kg once daily for 2–3 months) or with the new galenic preparation ekvalen (daily administration in a dose of 1.5 ml/kg in a 16–18% aqueous ethanol solution for 7 days at 3–4-day intervals during a 1–3-month period). Normalization of lipid metabolism in the enterohepatic system is documented.
Key Wordscholestasis lipid metabolism chenodeoxycholic acid galenic preparations
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- 1.Yu. A. Bogdarin,Peculiarities of Lipid Composition in the Enterohepatic System and Its Correction in Cholelithiasis, D. Sci. Dissertation [in Russian], Gorky (1990).Google Scholar
- 2.Yu. A. Bogdarin, A. V. Galkin, I. B. Denisova, and A. S. Vizgalova,Method of Preparation of Individual Bile Acids, Russian Federation Patent No. 166568 November 22, 1991.Google Scholar
- 3.Yu. A. Bogdarin,Drug for the Prevention and Treatment of Cholecystitis and Cholelithiasis, Russian Federation Patent No. 5068531, October 17, 1994.Google Scholar
- 4.Yu. P. Ipatov,Clinical Significance of X-Ray and Ultrasound Diagnostics of Gastroduodenal and Pancreatobiliar Disorders in Children, MD. Dissertation [in Russian], Gorky (1989).Google Scholar
- 6.A. S. Loginov, S. M. Chebanov, Yu. Kh. Marakhovskii, and I. I. Goncharik,Byull. Eksp. Biol. Med.,108, No. 8, 251–254 (1989).Google Scholar
- 7.Kh. Kh. Mansurov, in:Problems of Gastroenterology [in Russian], V. Kh. Vasilenko (Ed.), Vol. 7, Dushanbe (1987), pp. 9–20.Google Scholar
- 8.S. Ya. Sokolov and I. P. Zamotaev,A Reference Book of Medicinal Plants [in Russian], Moscow (1989).Google Scholar