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Potassium transport through the erythrocyte plasma membrane in patients with insulin-dependent diabetes mellitus: Effects of insulin therapy

  • Experimental Methods for Clinical Practice
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Abstract

Plasma membrane potential and function of Ca2+-activated K+ channels of erythrocytes are studied in patients with insulin-dependent diabetes mellitus. A significant increase in membrane potential and in the degree of opening of Ca2+-activated K+ channels is revealed in comparison with erythrocytes of healthy donors. The degree of channel opening is higher in patients with nephropathy than in those with retinopathy, in which this parameter is normal. Insulin therapy normalize the erythrocyte plasma membrane potential in the patients and has no effect on the degree of channel opening. Ion transport disturbances and modulations of Na+, K+, and Ca2+ levels in erythrocytes may impair their function in insulin-dependent diabetes mellitus.

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Authors and Affiliations

  1. Department of General pathology and Pathophysiology, Russian Medical Academy for Postgraduate Education, Moscow, Russia

    A. A. Kubatiev, T. S. Balashova, M. I. Balabolkin & E. N. Tomilova

  2. Endocrinology Department, Faculty of Advanced Medical Training, I. M. Setchenov Moscow Medical Academy, Moscow, Russia

    A. A. Kubatiev, T. S. Balashova, M. I. Balabolkin & E. N. Tomilova

Authors
  1. A. A. Kubatiev
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  2. T. S. Balashova
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  3. M. I. Balabolkin
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  4. E. N. Tomilova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 109–113, July, 1996

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Kubatiev, A.A., Balashova, T.S., Balabolkin, M.I. et al. Potassium transport through the erythrocyte plasma membrane in patients with insulin-dependent diabetes mellitus: Effects of insulin therapy. Bull Exp Biol Med 122, 748–751 (1996). https://doi.org/10.1007/BF02446041

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  • DOI: https://doi.org/10.1007/BF02446041

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