Abstract
The addition of amniotic fluid from pregnant women with anencephaly to neuronal and organotypic cultures initiated from germinal brain cortex of 8–12-week-old human embryos has no appreciable effect on growth and differentiation of neurons. However, it stimulates the formation of endothelial channels and affects cell-to-cell interactions. This is assumed to be a factor associated with an abnormal development of the CNS in anencephaly.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 87–90, July, 1996
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Bobryshev, Y.V., Dambinova, S.A., Pavlova, N.G. et al. Effect of amniotic fluid from patients with fetal pathology (anencephaly) on cell differentiation in nervous tissue culture. Bull Exp Biol Med 122, 728–730 (1996). https://doi.org/10.1007/BF02446036
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DOI: https://doi.org/10.1007/BF02446036