Abstract
Dynamic viscosity of blood and hepatic microcirculation were evaluated in two groups of male rats: rats with alloxan-induced diabetes mellitus to which acute toxic hepatitis was added by injection of the alkaloid heliotrine (group 1) and those with heliotrine-induced hepatitis to which diabetes was added by alloxan injection (group 2). While blood viscosity and hepatic microcirculation were altered in both groups (particularly on day 3 after hepatitis induction in group 1 and on day 14 after diabetes induction in group 2), the alterations were more strongly marked in group 1. The results of this study are interpreted as indicating an early decompensation of the mechanisms of adaptation (autoregulation) in the presence of these two diseases, especially when hepatitis is superimposed on diabetes.
Similar content being viewed by others
References
A. F. Blyuger,Klin. Med., No. 2, 51–59 (1987).
Kh. Ya. Karimov, in:Topics of Current Interest in Medicine [in Russian], Tashkent (1993), pp. 3–8.
Kh. Ya. Karimov, B. U. Iriskulov, and M. K. Ergashev,Byull. Eksp. Biol. Med.,116, No. 12, 584–585 (1993).
V. I. Udovichenko,Pat. Fiziol, No. 1, 73–75 (1978).
D. E. McMillan,Microcirc. Endothelium Lymphatics,1, No. 1, 3–34 (1984).
B. G. Stone and D. H. Van-Thiel,Semin. Liver Dis.,5, No. 1, 8–28 (1985).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 20–22, July, 1996
Rights and permissions
About this article
Cite this article
Karimov, K.Y., Iriskulov, B.U. & Askarov, K.A. Dynamic blood viscosity and hepatic microcirculation in alloxan-induced diabetes combined with toxic hepatitis. Bull Exp Biol Med 122, 666–668 (1996). https://doi.org/10.1007/BF02446016
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02446016