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Decreased sensitivity of adenylate cyclase to sodium ions in lymphocytes of patients with arterial hypertension

  • Biological Methods for Clinical Use
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Patients with arterial hypertension showed decreased sensitivity of isoproterenol-stimulated adenylate cyclase of mononuclear lymphocytes toward sodium ions compared with normotensive donors. Ouabain, an inhibitor of Na,K-ATPase, increased the half-maximal inhibition of adenylate cyclase activity by sodium ions in the cells of healthy subjects and did not change enzyme sensitivity to sodium in the lymphocytes of hypertensive patients.

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Authors and Affiliations

  1. Institute of Clinical Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, Moscow

    T. L. Krasnikova, O. A. Vikhert & A. V. Mazaev

Authors
  1. T. L. Krasnikova
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  2. O. A. Vikhert
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  3. A. V. Mazaev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 8, pp. 206–207, August, 1995

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Krasnikova, T.L., Vikhert, O.A. & Mazaev, A.V. Decreased sensitivity of adenylate cyclase to sodium ions in lymphocytes of patients with arterial hypertension. Bull Exp Biol Med 120, 849–850 (1995). https://doi.org/10.1007/BF02445972

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  • DOI: https://doi.org/10.1007/BF02445972

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