Cholinergic stimulation (acetylcholine, aceclidine, armin) is found to improve antiinfectious nonspecific resistance in mice. The effect depends on the dose of cholinomimetic (armin), is maximal during the first 18 hours of the infectious process, and is determined by serum antibacterial activity, lysozyme activity, and the function of neutrophils and natural killers.
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I. A. Gontova, V. V. Abramov, N. Yu. Gromykhina,et al., Immunologiya, No 4, 52–55 (1989).
S. M. Gordienko,, No 1, 31–36 (1984).
P. P. Denisenko, in:The Role of Cholinergic Systems in Regulatory Processes [in Russian], Moscow (1980), pp. 165–195.
P. F. Zabrodskii and V. N. Kazakov,Zh. Mikrobiol., No 2, 32–36 (1988).
Evaluation of the Immunological Status of the Organism in Soviet Army and Navy Medical Institutions (Manual) [in Russian], Moscow (1987).
B. H. Dulis, M. A. Gordon, and I. B. Wilson,Mol. Pharmacol.,15, No 1, 28–34 (1979).
J. Ferluga, G. L. Asherson, and E. L. Becker,Immunology,23, No 4, 577–590 (1972).
E. Grabczeowska, H. Lakowska-Bozek, W. Maslinski, and J. Ryzewsri,Rheumatology,28, No 4, 170–179 (1990).
C. Y. Li, K. W. Lam, and L. T. Yam,J. Histochem. Cytochem.,21, No 1, 1–12 (1973).
A. Loran,Lancet, No 8816, 420–421 (1992).
G. Millington and J. C. Buckingam,J. Endocr.,133, No 2, 163–168 (1992).
J. M. Quiroz and L. A. Oliveina,Rev. Brasil. Pesquesis Med. Biol.,8, No 2, 119–123 (1975).
I. Rinner and K. Schauenstein,J. Neuroimmunol.,34, No 2-3, 165–172 (1991).
H. Techima, H. Sodama, H. Kihara, and T. Nakagama,Fukuoka Acta Med.,82, No 7, 428–436 (1991).
J. F. Whitfield, J. P. MacManus, H. R. Rixon,et al., In Vitro Cell. Dev. Biol,12, No 1, 1–18 (1976).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No. 8, pp. 164–166, August, 1995
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Zabrodskii, P.F. Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation. Bull Exp Biol Med 120, 809–811 (1995). https://doi.org/10.1007/BF02445960