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Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation


Cholinergic stimulation (acetylcholine, aceclidine, armin) is found to improve antiinfectious nonspecific resistance in mice. The effect depends on the dose of cholinomimetic (armin), is maximal during the first 18 hours of the infectious process, and is determined by serum antibacterial activity, lysozyme activity, and the function of neutrophils and natural killers.

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  1. 1.

    I. A. Gontova, V. V. Abramov, N. Yu. Gromykhina,et al., Immunologiya, No 4, 52–55 (1989).

    Google Scholar 

  2. 2.

    S. M. Gordienko,, No 1, 31–36 (1984).

    Google Scholar 

  3. 3.

    P. P. Denisenko, in:The Role of Cholinergic Systems in Regulatory Processes [in Russian], Moscow (1980), pp. 165–195.

  4. 4.

    P. F. Zabrodskii and V. N. Kazakov,Zh. Mikrobiol., No 2, 32–36 (1988).

    PubMed  Google Scholar 

  5. 5.

    Evaluation of the Immunological Status of the Organism in Soviet Army and Navy Medical Institutions (Manual) [in Russian], Moscow (1987).

  6. 6.

    B. H. Dulis, M. A. Gordon, and I. B. Wilson,Mol. Pharmacol.,15, No 1, 28–34 (1979).

    PubMed  CAS  Google Scholar 

  7. 7.

    J. Ferluga, G. L. Asherson, and E. L. Becker,Immunology,23, No 4, 577–590 (1972).

    PubMed  CAS  Google Scholar 

  8. 8.

    E. Grabczeowska, H. Lakowska-Bozek, W. Maslinski, and J. Ryzewsri,Rheumatology,28, No 4, 170–179 (1990).

    Google Scholar 

  9. 9.

    C. Y. Li, K. W. Lam, and L. T. Yam,J. Histochem. Cytochem.,21, No 1, 1–12 (1973).

    PubMed  CAS  Google Scholar 

  10. 10.

    A. Loran,Lancet, No 8816, 420–421 (1992).

    Google Scholar 

  11. 11.

    G. Millington and J. C. Buckingam,J. Endocr.,133, No 2, 163–168 (1992).

    PubMed  CAS  Article  Google Scholar 

  12. 12.

    J. M. Quiroz and L. A. Oliveina,Rev. Brasil. Pesquesis Med. Biol.,8, No 2, 119–123 (1975).

    Google Scholar 

  13. 13.

    I. Rinner and K. Schauenstein,J. Neuroimmunol.,34, No 2-3, 165–172 (1991).

    PubMed  CAS  Article  Google Scholar 

  14. 14.

    H. Techima, H. Sodama, H. Kihara, and T. Nakagama,Fukuoka Acta Med.,82, No 7, 428–436 (1991).

    Google Scholar 

  15. 15.

    J. F. Whitfield, J. P. MacManus, H. R. Rixon,et al., In Vitro Cell. Dev. Biol,12, No 1, 1–18 (1976).

    CAS  Article  Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No. 8, pp. 164–166, August, 1995

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Zabrodskii, P.F. Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation. Bull Exp Biol Med 120, 809–811 (1995).

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Key Words

  • cholinergic stimulation
  • antiinfectious resistance
  • nonspecific factors of the organism's resistance
  • natural cytotoxicity